Pasadena’s EvoRx Technologies Completes Year-long Collaboration with Major Global Biopharmaceutical

first_img faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Virtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyCitizen Service CenterPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena 8 recommended0 commentsShareShareTweetSharePin it EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Name (required)  Mail (required) (not be published)  Website  Business News Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy More Cool Stuff Pasadena-based biotechnology company EvoRx Technologies has completed a year-long research collaboration with the global biopharmaceutical firm AstraZeneca aimed at improving drug delivery to treat patients with diseases that have not been accessible with traditional strategies.The collaboration leveraged EvoRx’s proprietary Evo-Link technology which aims to rapidly develop more potent and cell permeable peptide compounds that can be orally administered to treat patients especially with respiratory diseases.At the end of the research work, EvoRx reported that their team had successfully generated peptides that could eventually result in a more potent drug-delivery process, which is the primarily goal of the collaboration.“This collaboration allowed us to further validate our unique approach in successfully targeting intracellular protein-protein interactions thought to be undruggable,” Stephen Fiacco, EvoRx CEO, said. “Our new therapeutic paradigm has the potential to be a game changer for many patients with diseases that so far have not been accessible with traditional strategies in drug discovery. This opens the door for novel treatment across many therapeutic areas.”EvoRx said nearly 70 percent of proteins implicated in diseases are considered “undruggable,” or inaccessible to drugs using traditional treatment approaches. The company’s Evo-Link technology seeks to address this deficiency.Dr. Maarten Kraan, head of the Respiratory, Inflammation and Autoimmune Diseases Innovative Medicines Unit at AstraZeneca, said they were able to make “very significant progress on the permeability problem” of their peptides with the collaboration with EvoRx.“Many disease targets are intractable to both small molecule and biologic therapy, limiting our options to discover new treatments for these life-threatening and debilitating diseases,” Kraan said. “Designing potent, stable, cell penetrating peptides is also one of our industry’s biggest challenges, and so we are delighted with the outcome of our collaboration with EvoRx Technologies.”AstraZeneca will continue to develop the cell-penetrating peptides after the end of the collaboration.EvoRx, with offices and laboratories at 129 N. Hill Avenue in Pasadena, is a privately held company founded in 2011 which strives to develop innovative peptide therapeutics and targeted radiopharmaceuticals for treatment and diagnosis of diseases.More information about the company and its work is available at their website, www.evorxtechnologies.com. Top of the News center_img Community News First Heatwave Expected Next Week Community News Company News Briefs Pasadena’s EvoRx Technologies Completes Year-long Collaboration with Major Global Biopharmaceutical From STAFF REPORTS Published on Thursday, July 9, 2015 | 12:52 pm Your email address will not be published. Required fields are marked * Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Make a comment Subscribe HerbeautyShort On Time? 10-Minute Workouts Are Just What You NeedHerbeautyHerbeautyHerbeautyWeird Types Of Massage Not Everyone Dares To TryHerbeautyHerbeautyHerbeautyWant To Seriously Cut On Sugar? You Need To Know A Few TricksHerbeautyHerbeautyHerbeauty6 Strong Female TV Characters Who Deserve To Have A SpinoffHerbeautyHerbeautyHerbeautyWho Was The Hollywood ‘It Girl’ The Year You Were Born?HerbeautyHerbeautyHerbeauty15 Countries Where Men Have Difficulties Finding A WifeHerbeautyHerbeautylast_img read more

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Press release: Ofsted Chief Inspector launches her second Annual Report on state of education and children’s care in England

first_img As long as children are attending schools that are perpetually less than good, we have a problem. What makes the inequity even starker is that many of these schools are concentrated in particular parts of the country, serving the same demographic groups – often the white working class. I make no apology for not giving these schools an easier judgement; I’d never want us to be saying that this education wouldn’t do for Chelsea children, but it’s good enough for Grimsby. The moment we allow for a different quality of education based on demographics is the moment we concede defeat in the battle for equality of opportunity. It would be the moment we wrote off the Einsteins, Mozarts and Brontes of the future who don’t happen to grow up on the right side of the tracks. Instead, we need a real focus on improving standards in areas and schools that lag behind. We need to inject capacity. In the FE sector, there is potential for a dilution in the quality of apprenticeships. There are common issues around poor governance, low-quality teaching and not enough off-the-job training. Ofsted is also concerned about access to apprenticeships for students who leave school without a full level 2 qualification. Launching her second Annual Report as Her Majesty’s Chief Inspector, Amanda Spielman said today that, thanks to the hard work of teachers, lecturers, childminders, social workers and many others, the quality of education and care in England is good and improving: Instead, to put all children on the path to success, the most important thing is to get the basics right, which begins with early literacy. But the Annual Report finds that getting the basics right for one group of children is not always translating to getting it right for another.The phonics screening check has had a major impact on the standard of early reading, with year-on-year increases in the proportion of children reaching the expected standard on the check. However, the percentage of children on free school meals (FSM) who reach the expected standard on the check is 12 percentage points lower than their more affluent peers. There should be no reason for this, because the check is one of reading mechanics. Schools that focus on early reading make a major difference. Others need to do more. To support them, Ofsted will propose changes in the new education inspection framework that strengthen the focus on early reading.There is also stark regional variation here, but not the usual pattern of advantage versus disadvantage. Areas such as Newham and Newcastle, which educate high proportions of disadvantaged children, excel in making sure that pupils eligible for FSM perform well on the phonics check. At the same time, more affluent areas like West Berkshire lag behind.The Annual Report also highlights concerns raised by Ofsted’s local area SEND inspections. These have shown that provision for young people with special educational needs and/or disabilities (SEND) is too disjointed and inconsistent. Diagnoses are taking too long and are often inaccurate. Mental health needs are not supported sufficiently. The quality of education, health and care (EHC) plans is far too variable. Critically, the gap in performance and outcomes for children with SEND is widening between the best and worst local areas. Crucial to delivering a good service is having the right resources, a qualified workforce and strong leadership in order to be good or better. However, the Annual Report finds that in too many cases, the capacity for improvement does not exist.There are almost 500 ‘stuck’ schools across England that have been judged inadequate or requires improvement at every inspection since 2005. This means that some children may have been in a failing school for their entire time at secondary school. More outstanding schools and school leaders are needed to help these schools improve.Across the country, turnaround rates for underperforming schools remain too slow. A lack of sponsor capacity means some schools have been left in limbo for over 18 months before joining a multi-academy trust (MAT). The Annual Report argues that the current halfway-house approach to academisation is not working and calls for incentives to be reinstated to encourage the best schools to become academies and to use their expertise to sponsor.Ms Spielman continued: Speaking to an audience of education and social care professionals, local authority representatives and policy experts in Westminster, Ms Spielman said that there has been real progress, but there is still much more to do: In children’s social care, funding for statutory services has largely been protected locally. However, reductions in funding for other areas, such as youth services, mean demand has been pushed downstream because LAs are less able to intervene early when young people need help. The Annual Report provides a summary of Ofsted’s findings from inspections, visits and research over the past year. It presents a ‘state of the nation’ commentary on the quality of education, training and care services in England.This year’s report is clear that, across the sectors Ofsted inspects, people are working incredibly hard to deliver for young people. However, the Chief Inspector said today that underneath the headline success, deep inequities remain.Ms Spielman continued: teacher workload and well-being managing the most challenging behaviour in schools how faith schools successfully navigate potential conflicts between their religious beliefs and equality legislation physical development in the early years curriculum the 16 to 19 curriculum curriculum knowledge and pedagogy in initial teacher education factors leading to good decisions for children in care creating the environments for great social work practice to thrive Between 2016 and 2017, 19,000 pupils dropped off school rolls between Years 10 and 11 and around half did not reappear on the roll of another state-funded school. This is a huge cause for concern. Ofsted’s new education inspection framework will empower schools to always put the child first, and it will allow inspectors to report on those schools that off-roll young people who might achieve less well. This paints a positive picture for much of the country. However, the Ofsted Annual Report finds that some young people still have the deck stacked against them. It calls for policy makers and practitioners to redouble their efforts to tackle these challenges and drive up standards in the years ahead. The Chief Inspector urged policy makers to avoid searching for the latest gimmicks from the tech world to tackle these problems, saying: 95% of early years providers are judged good or outstanding 76% of further education (FE) colleges and 86% of schools are at least good 82% of children’s homes are good or better the number of local authorities (LAs) judged good or outstanding for children’s services continues to risecenter_img There are still children who lag behind. Children, for whom it seems the die is cast, even before entering nursery, and who never catch up in 12 years of schooling. Wealth remains a predictor, albeit a weaker one, of educational performance. And despite promises from policy makers, FE is too often seen as a poor relation to schools, somewhere for ‘other people’s children’, while the outlook for too many children in contact with the care system remains bleak. New problems have emerged as well. A child in Hackney is more likely to fulfil their potential than ever before, but in some of our coastal towns and white working class communities, attainment, progress and aspiration are too low. Sink schools may have disappeared, but some schools that haven’t improved for more than a decade remain. Our colleges look less financially secure than in the past. Across the whole education sector a mentality of ‘what’s measured is what gets done’ trumps the true purpose of education, and curriculum thinking–the consideration of what needs to be taught and learned for a full education–has been eroded. The counterpart in social care is that while statutory services have largely been protected from funding cuts, early help and prevention have indeed been cut back. And schools have become another front in the new culture wars, expected to tackle an ever growing list of societal issues. Some policy makers and practitioners are constantly looking for the next magic potion that will infallibly raise standards or reduce the numbers of children in care. Indeed, despite the history of snake oil, white elephants and fashionable gimmicks that have in the main been debunked, there remains a curious optimism that the elixir of education is just around the corner. But the truth is, we don’t need an elixir to help raise standards, because we already have the tried and tested ingredients we need. Other areas of concern highlighted in the Annual Report In some early years settings, children’s physical development is being hindered by undue concerns about health and safety requirements; some level of risk is essential in childhood. Without it, children are denied opportunities to build muscular strength and dexterity. There is a group of young people who seem to have the deck stacked against them. I often liken the path through education to a slope. For affluent and high ability children the slope is, in general, fairly shallow, and the path to reaching their potential only moderately challenging. For others from poorer backgrounds, who face challenges in the home, or who struggle with learning, the gradient is steeper and the path is harder. Our job as education and care professionals is to reduce that gradient, to make that path shallower. And perhaps the most important thing we can do to reduce that gradient is to get the basics right. Spending per student in an FE or sixth form college is now 11% lower than for pupils at secondary school. Ofsted is concerned about the college sector’s financial sustainability and the impact that funding cuts can have on provision. Read the Ofsted Annual Report. SEND in mainstream schools In January, Ofsted will consult on the new education inspection framework and handbooks. This will give the sector a real opportunity to shape the future of inspection. The framework is being piloted throughout the autumn term until July 2019, with information and training sessions for schools running in parallel. Subject to the consultation, the new framework will take effect from September 2019.Research programmeOver the next year, Ofsted’s research programme will explore many of the themes discussed in the Annual Report. This will include projects looking at: In addition, Ofsted will be working with the Department for Education to look at ‘stuck schools’ and what they can do to improve.last_img read more

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Clayton Kershaw clinches the division for the Los Angeles Dodgers — and maybe an MVP award

first_imgThe best moments in sports are usually authored when the action deviates from the script. For the sold-out crowd at Dodger Stadium on Wednesday, a Hollywood ending was good enough.Dodgers starter Clayton Kershaw (21-3) allowed one run in eight innings to beat the rival San Francisco Giants, leading the Dodgers to a 9-1 victory that clinched the National League West title.Kershaw hit his first career triple to drive in the Dodgers’ first run, then watched as Yasiel Puig homered in the sixth inning to give the Dodgers a 2-1 lead they would not relinquish. The 26-year-old pitcher might have made a prophet of the 53,387 fans in attendance, who were standing and shouting “M-V-P” in near unison as he walked off the mound.The victory assured the Dodgers of their second straight division title and an automatic trip to the National League Division Series, which begins Oct. 3. Their opponent — either the Washington Nationals or St. Louis Cardinals — will be determined over the final four days of the regular season.The Dodgers can enjoy a well-earned day off today, a time for manager Don Mattingly to begin formulating his NLDS roster.Baseball’s awards voters, meanwhile, can contemplate their ballots. Kershaw might become the first pitcher to win the National League MVP award since Bob Gibson in 1968. If not that and a third Cy Young Award — a cinch at this stage of the season — Kershaw is assured a place in baseball’s record books. If he doesn’t pitch another inning before the playoffs, Kershaw will finish with a major-league leading 1.77 earned-run average. No pitcher has led the majors in ERA in four straight seasons. Kershaw also leads the National League in wins (21) and strikeouts (239) despite not pitching the entire month of April.One more stat to consider: In four starts this season against the Giants, the Dodgers’ only rival for a division title, Kershaw went 3-0 and allowed six runs. He averaged eight innings in those four starts.Wednesday’s game was a tense battle until Puig’s home run off Giants starter Tim Hudson (9-13) sparked a four-run inning, turning a 1-1 tie into a 5-1 Dodgers lead. The Dodgers added four more runs in the eighth inning off the Giants’ bullpen to seal the deal.Puig wowed the crowd with his bat and his arm, throwing out Gregor Blanco trying to go from first to third on a single in the seventh inning. He leads the National League with 14 outfield assists.Carl Crawford and Juan Uribe each had two of the Dodgers’ eight hits. Uribe missed a home run just a few feet wide of the foul pole in left field.Former Giants closer Brian Wilson closed out the game with a scoreless ninth inning.The Dodgers enjoyed a postgame celebration fueled by 24 cases of beer, 204 bottles of champagne and four cases of Martinelli’s sparkling cider. Major League Baseball does not permit alcohol on its fields.center_img Newsroom GuidelinesNews TipsContact UsReport an Errorlast_img read more

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