Switzerland v HoundurasFri 25 June [World CupSchedule](http://www.skyscanner.net/news/articles/2010/04/005224-south-africa-world-cup-2010—schedule.html)| | Great deals on packages to theSouth Africa World Cup [World CupGroups](http://www.skyscanner.net/news/articles/2010/04/005225-south-africa-world-cup-2010—groups.html) —|—|—|— [World CupVenues](http://www.skyscanner.net/news/articles/2010/04/005220-south-africa-world-cup—venues.html)| France v South AfricaTue 22 June [World CupHome](http://www.skyscanner.net/news/articles/2010/04/005215-south-africa-world-cup—home.html)| [World CupTeams](http://www.skyscanner.net/news/articles/2010/04/005223-south-africa-world-cup-2010—teams.html)| FixturesDate Japan v CameroonMon 14 June Slovakia v ParaguaySun 20 June [World CupDestinations](http://www.skyscanner.net/news/articles/2010/04/005221-south-africa-world-cup-2010—destinations.html)| Get on the ball for less with Skyscanner [World CupNews](http://www.skyscanner.net/news/articles/south-africa-world-cup-news/)| Greece v NigeriaThu 17 June Cheap flightsto South Africa [World CupPackages](http://www.skyscanner.net/news/articles/2010/04/005233-south-africa-world-cup-2010—packages.html) Save more on hotelsin South Africa Free State StadiumBloemfontein, Free State ProvinceMore or less slap bang in the middle of South Africa is Bloemfontein/Mangaung which in the seSotho language means “place of cheetah”. The city is famous for its fanatical sports supporters, and there should be a lively atmosphere there when the tournament hosts take on France. The stadium had been recently revamped and now can now seat 45,000 people. This is largely a rural area and natural beauty will be an attraction for many; but at the same time the city is lively and vibrant with plenty of shops and malls and a busy night life.Distance from Johannesburg: 420kmDistance from Durban: 670 kmDistance from Cape Town: 1000kmMatches: | Great deals on car hirein South Africa ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map RelatedSouth Africa World Cup 2010 – VenuesSouth Africa World Cup 2010 – VenuesSouth Africa World Cup 2010 – BloemfonteinSouth Africa World Cup 2010 – BloemfonteinSouth Africa World Cup 2010 – Nelson Mandela Bay Stadium, Port Elizabeth, Eastern Cape ProvinceSouth Africa World Cup 2010 – Nelson Mandela Bay Stadium, Port Elizabeth, Eastern Cape Province
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20Jun Caro Center expansion receives conference report approval State Sen. Mike Green and state Rep. Edward J. Canfield, D.O. on Tuesday announced that Caro will be home to a new regional psychiatric hospital.“Today’s announcement that the new state hospital will be constructed at the site of the current Caro Center is a direct reflection of the strong community support for this facility,” said Green, R-Mayville.The Capital Outlay portion of the fiscal year 2018 budget will include both planning and construction authorization for a new state hospital at the existing Caro Center location.The state was considering a new location for this facility, but Green and Canfield were successful in keeping the expansion in Tuscola County.“The Caro Center has been providing top-notch care for over 100 years, and with over 350 full-time employees, it is a critical employer in Tuscola County,” said Canfield, R-Sebewaing. “Moving it would devastate the county’s economy and make receiving proper treatment significantly more difficult for many patients.”The lawmakers point to data that shows more than 80 percent of the center’s patients come from a bordering county, or from the south and east, which is still considered to be a reasonable driving distance. Data also shows about a third of the facility’s employees live in a Caro ZIP code and over 70 percent of workers live within 30 miles of the Caro Center.“I want to especially thank Rep. Canfield for his tireless work in making sure this got done,” Green said. “From Tuscola County and beyond, we would like to personally thank all who contacted the governor to express their commitment to keeping Caro Center.”Canfield echoed Green’s sentiments.“I would especially like to thank the governor for listening to our constituents and agreeing that the present location is best for the new facility,” Canfield said. “This was a true example of a representative government working for the people.”House Bill 4323, which includes the project language, will now go before the Senate and House of Representatives for a final vote. Categories: Canfield News,News
Categories: Annette Glenn News Rep. Annette Glenn, of Midland, will hold a special town hall meeting on road funding on Thursday, June 20 from 6 to 7 p.m. at the Midland County Road Commission, 2234 N. Meridian Road in Sanford. Special guest Rep. Jack O’Malley, chairman of the House Transportation Committee will be joining her.“The current shape of our roads and bridges in Michigan is unacceptable,” Glenn said. “This will be an opportunity for constituents in Bay and Midland counties to share your stories, feedback, and ideas with Chairman O’Malley and me, and a chance for us to explain our plan to fix our roads and bridges without raising taxes or taking funds away from schools or other taxpayer priorities. I look forward to seeing as many families, senior citizens, business owners, and other drivers there as possible.”Doors will open at 5:30, and discussion will occur from 6 to 7 p.m. with time allotted for questions. The event is open to the public and there is no cost to attend.For more information, please contact Rep. Glenn’s office at (517) 373-1791 or AnnetteGlenn@house.mi.gov. 11Jun Rep. Glenn invites residents to town hall meeting on road funding
Copyright 2018 NPR. To see more, visit http://www.npr.org/.
The next time you swat a fruit fly in your kitchen, take heart from the fact that people have apparently been struggling with these fly infestations for around 10,000 years.A study published Thursday suggests Drosophila melanogaster first shacked up with humans when the insects flew into the elaborately painted caves of ancient people living in southern Africa.That’s according to a report published Thursday in the journal Current Biology.Scientists say the flies would have been following the alluring smell of stored marula fruit, which were collected and stored by cave-dwelling people in Africa. This tasty yellow fruit was a staple in the region in those days — and was also the fruit that wild flies apparently evolved to depend on in nearby forests.The humble fruit fly now lives with humans all over the planet and is one of the world’s most studied creatures. For more than a century, biology and medical laboratories have depended on this fly — one scientist notes that at least nine times, the Nobel Prize in Physiology or Medicine has been awarded for research on Drosophila. One of those prizes was won by Thomas Hunt Morgan of Columbia University, whose fly research in the early 1900s plucked this species from obscurity and transformed it into a mainstay of genetics.”It’s small; it’s cheap to raise; it has interesting genetics,” explains Thomas Kaufman, a biologist at Indiana University in Bloomington. “We think that flies are quite charismatic. They’re wonderful. They’re beautiful little animals, and we love them. Seriously.”But despite all that love and study, the origins of this fly, and how it first moved in with people, have been a mystery.”I’ve been wondering about this for the past 20 years,” says Marcus Stensmyr, a biologist at Lund University in Sweden who uses these flies to study the olfactory system. “It’s really been kind of a life-long ambition, if you wish, to find where they come from.”Scientists have known for decades that, like people, the flies seem to have started out in Africa — somewhere.”You find them in your kitchen. You find them in my kitchen — you find them in everyone’s kitchen,” says Stensmyr. “But if you go out into the forest, you simply don’t find them.”Recently, researchers collected flies from around Africa and looked at their genes. They found that the greatest genetic diversity was found in flies from Zambia and Zimbabwe, suggesting that this species got its start in the southern-central region of the continent.But trips to that region failed to turn up much of anything.”After a number of failed excursions down to Africa,” says Stensmyr, “we thought, ‘OK, so maybe they are associated with some specific fruit in their original home.’ “Stensmyr and his colleagues studied a long list of possible fruits, looking for all the features that D. melanogaster is known to prefer. The flies favor citrus fruits — like oranges, for example.”We came to a candidate fruit — that was marula fruit,” says Stensmyr. The yellow fruit is about the size of a large plum, with a hard stone in the middle. “It has a sweet and nice taste.”The researchers traveled to the woodlands of the Matobo National Park in Zimbabwe. They found fruiting marula trees and put out traps. Bingo — they caught D. melanogaster.”We found tons of flies,” Stensmyr recalls.Further study showed that wild D. melanogaster strongly prefer marula fruit over oranges.What’s more, so does a breed of fly that’s commonly used in labs. This strain was established in 1916 from a fly population in Canton, Ohio.”They actually have retained the preference for marula,” says Stensmyr. “They would go for the marula as well.”The researchers isolated one particular chemical in this fruit — ethyl isovalerate — that seemed particularly important. Flies that were given a choice between marula and oranges spiked with this chemical failed to pick one over the other, suggesting that the two choices seemed the same to the flies.All of this provides an intriguing clue for how these insects may have started to make their home with people. Near where the researchers found the wild flies, there are caves where the San tribes once lived. These people left behind beautiful cave paintings — as well as the pits of marula fruit that they had eaten. From one cave alone, excavators turned up 24 million marula stones.”They really, really loved marula,” says Stensmyr, who points out that the stones found date from about 12,000 years ago to about 8,000 years ago. “During the times when these caves were inhabited, the San people must have brought enormous quantities of marula into the caves.”That means marula was likely stored there, and available there long after the marula in the forest had been eaten up by wildlife. The strong smell of all this marula would have attracted the flies.To test whether or not wild flies would actually enter a cave, the research team put traps baited with fermenting marula along the far wall of the Nswatugi cave. Sure enough, over a period of a few days, these traps caught a number of D. melanogaster flies.The study, and the story it tells, has completely delighted other scientists who study fruit flies.”I particularly liked going and catching the flies in the painted caves,” says Kaufman. “That was inspired. It’s really a neat paper.””I thought it was fantastic,” agrees Celeste Berg, a developmental geneticist at the University of Washington, Seattle who has used flies in her research for 30 years. “I thought their data was really quite striking.”Berg says she wonders exactly how the flies would have spread from these caves to the rest of the world.”I think it’s exciting to learn the origins of fruit flies and, even if you’re not an ecologist or a population geneticist, I think it’s just natural to be interested in the history of the organism you study,” says Berg. “I had assumed that fruit flies liked all kinds of fruit — especially bananas. I didn’t even realize that they preferred citrus. And it’s not even really citrus that they prefer; they prefer this particular marula plant, which I also had never heard of.”Debbie Andrew, a developmental biologist at the Johns Hopkins School of Medicine who has worked with fruit flies for four decades, also says she loved the paper.”They built a good story,” says Andrew. “It’s very hard to prove something that happened 10,000 years ago or more. I like the story.”As to whether all the details are right, she says, “I don’t know; it does seem plausible, based on the amount of marula fruit stones they found in the cave.”Based on this paper, says Andrew, the old saying, “time flies like an arrow, and fruit flies like a banana,” should really be changed.”Time flies like an arrow,” she says, “and fruit flies like an orange, or a marula fruit, or perhaps an orange spiked with ethyl isovalerate.” Copyright 2018 NPR. To see more, visit https://www.npr.org.
Two groups have been chosen to set up new centres for independent living (CIL) in Wales, doubling the number of CILs in the country.The new centres will be located in Ceredigion, in the west of the country, and Flintshire, in the north, and will both be run and controlled by disabled people.Although there are only two existing CILs in Wales, the long-term aim is to have one in every one of its 22 counties.The two new CILs were selected by Disability Wales, the Wales Co-operative Centre (WCC), and Dewis Centre for Independent Living, as part of the £318,000 Welsh government-funded Enabling Wales programme.Disability Wales said it hoped they would provide “a kick start to developing more CILs across Wales”.The two groups will now receive support from Disability Wales, WCC and Dewis CIL as they work towards opening their doors to disabled people next March.That support will include help with the bids they will need to make to local authorities, the Welsh government and other sources of funding to allow them to meet their running costs.Disability Wales said the two groups would need to “strike a balance between their traditional campaigning role… with the need to operate successfully within a highly competitive commercial environment, and to manage the potential conflicts of interest when delivering public contracts”.The Ceredigion CIL will focus on providing information and advice – including disability equality training; self-advocacy; offering support to victims of hate crime; campaigning; and fundraising – and will be run by the disabled people’s organisation Disabled People Together, as well as the non-user-led groups Mencap Ceredigion and Creative Lifestyle Solutions.Rhiannon Hicks, Enabling Wales project officer at Disability Wales, said: “The Ceredigion group were successful as they showed a strong understanding of organisations led by disabled people for disabled people.“They also have a strong commitment to the social model of disability, as well as good partnerships with relevant third sector bodies.”The Flintshire CIL will be run by the user-led Flintshire Disability Forum (FDF), and will provide services such as help with managing personal budgets; campaigning; recruitment and training of personal assistants; assistance completing application forms; and equipment hire.Hicks said: “The FDF were successful as they have a strong track record of project delivery, and of securing funding. They also have strong partnerships.”She added: “I very much look forward to working with both groups in the next stage of the project.”Rhian Davies (pictured), director of Disability Wales, said: “We are delighted that following an 18-month long programme of training, development and coaching, working with 65 disabled people across Wales, we have achieved our goal in being able to select two emerging CILs and support their development over the remainder of the Enabling Wales project.“CILs are social enterprises that deliver services run by disabled people for disabled people and offer a new and creative model of provision in line with what people actually need to achieve independent living and well-being as well as maximise scarce resources.”Disability Wales said it hoped the new organisations would in time be able to support other groups towards becoming CILs, while it would itself be providing a “tool kit” on how to set up a CIL.Carl Sargeant, the Welsh government’s cabinet secretary for communities and children, congratulated the two groups, and said: “I am sure that, with the support of the Wales Cooperative Centre and Dewis CIL, they will develop and grow into sustainable enterprises which will promote independent living for disabled people and provide them with the services they need to support their well-being.”Picture by Natasha Hirst
Source:https://c-path.org/c-path-receives-qualification-from-fda-for-the-asthma-daytime-symptom-diary-adsd-and-the-asthma-nighttime-symptom-diary-ansd/ Reviewed by James Ives, M.Psych. (Editor)Apr 10 2019Critical Path Institute’s (C-Path) Patient-Reported Outcome (PRO) Consortium announces U.S. Food and Drug Administration (FDA) qualification of two new clinical outcome assessment tools: the Asthma Daytime Symptom Diary (ADSD) and the Asthma Nighttime Symptom Diary (ANSD). The qualification of the ADSD and the ANSD represents a major milestone for the PRO Consortium and specifically for the Asthma Working Group. It is the culmination of a multi-year collaboration between FDA’s Center for Drug Evaluation and Research (CDER) and the PRO Consortium.The ADSD and the ANSD are each 6-item, PRO measures developed to document the core symptoms of asthma in adults and adolescents with a clinical diagnosis of mild to severe persistent asthma.”Asthma symptoms have a substantial impact on patients, including limiting the ability to participate in daily activities and disrupting sleep. The qualification of the ADSD and the ANSD is a significant advance in our ability to document the patient’s experience of asthma symptoms in clinical trials,” stated Linda Nelsen, MHS, Senior Director and Head, Patient Centered Outcomes, Value Evidence and Outcomes, at GlaxoSmithKline and co-chair of the PRO Consortium’s Asthma Working Group.”The development of the ADSD and ANSD represents a close collaboration of clinicians, measurement experts, and regulators focused on developing a robust measure of asthma symptoms,” Nelsen added. “Most importantly, the ADSD and ANSD were developed with extensive involvement of people living with asthma to clearly define the experience of asthma symptoms and the relative importance of those symptoms from their perspective. Thus, the ADSD and ANSD bring the patient’s voice into clinical trials in a way that allows the quantification of important concepts of patient experience in treatment.”Related StoriesWorld Asthma Day: How climate change is increasing cases of asthmaGrowing up on farm with animals may half risk of asthma and allergies, suggests studyChaos in the house and asthma in children – the connectionSonya Eremenco, MA, Associate Director of the PRO Consortium, said, “Sponsors of asthma treatment trials have been using a variety of asthma symptom measures over the years, but we now have a standard set of symptom measures created via a multi-stakeholder, precompetitive collaboration that can be used in asthma drug development programs. This is a significant step toward providing enhanced consistency and comparability in the evaluation of the patient-focused clinical benefit from new asthma drugs.”CDER has determined that the ADSD and ANSD have demonstrated adequate evidence of content validity and cross-sectional measurement properties (i.e., internal consistency reliability, test-retest reliability, convergent validity and known-groups validity) to measure symptoms of asthma in adolescents and adults.Drug developers seeking to use the ADSD or ANSD as a primary or secondary endpoint measure in confirmatory studies should discuss plans with the appropriate CDER review division. It is recommended to use the ANSD with the ADSD to better characterize the drug effect and understand the measurement properties of each instrument. Further evaluation is needed on the instruments’ longitudinal properties and the interpretation of clinically meaningful within-patient change in score.