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Wijnaldum Liverpool are not focusing on title battle

first_imgLiverpool midfielder Georginio Wijnaldum insists they are focusing on themselves and not on Manchester City’s results ahead of tonight’s game at WolvesAfter 17 games, Jurgen Klopp’s side remains unbeaten with a one-point advantage over City at the top of the Premier League.But Wijnaldum, who impressed in last Sunday’s 3-1 win against Manchester United, says Liverpool are only keeping focus on themselves.And the Dutchman expects a stern challenge from Wolves, who defeated Chelsea 2-1 earlier this month at home.“This season we didn’t think about getting close to City,” Wijnaldum told the club website.divock origi, liverpoolReport: Origi cause Klopp injury concerns George Patchias – September 14, 2019 Divock Origi injury in today’s game against Newcastle is a cause for concern for Jurgen Klopp.Perhaps with one eye on Tuesday’s trip to Italy…“When we were in the future situations [playing after them], or in this case to go four points ahead.“We don’t really think about that, we just want to play the game and try to win the game and then we will see what will happen at the end of the week. We just have to make sure we win our game, that’s the only thing we have to do.“I think Wolves have shown already against the ‘big’ teams that they are a good playing side, especially at home, so it’s going to be a really, really tough game.“We know we have to be 100 per cent concentrated to win that game.”A win tonight at Molineux will move Liverpool four points clear over City, who face Crystal Palace on Saturday.last_img read more

Blazers win streak reaches 10 games

first_imgOAKLAND, Calif. — Wes Matthews had a pretty good seat for Portland’s 10th straight win. It just happened to be in the Trail Blazers’ locker room.One of three players ejected in the third quarter following a scuffle with Golden State, Matthews spent the final 15 minutes watching the game on TV with teammate Mo Williams after both players were tossed.The two players saw yet another dramatic comeback by one of the biggest surprise teams in the Western Conference.LaMarcus Aldridge had 30 points and 21 rebounds and the Trail Blazers beat the Warriors 113-101 on Saturday.“That inspired us,” said Matthews of the altercation that resulted in six technical fouls in addition to the ejections. “We got better from it, we got stronger from it. Mo and I were continuing to cheer. They couldn’t hear us, but we were continuing to cheer.”One night after rallying from 21 down to beat the Chicago Bulls 98-95, Portland again had to play from behind, but rode a big fourth quarter from Aldridge to keep the winning streak going.Aldridge made 11 free throws in the fourth quarter to highlight his sixth double-double this season. Matthews had 23 points while Bay Area native Damian Lillard added 20 points and nine assists for the Blazers.“We rode LaMarcus in the second half,” Portland coach Terry Stotts said. “He took it inside, got to the free throw line, made his free throws, offensive rebounds. He did it all and we rode him.”last_img read more

Captain Marvel postcredits scenes explained

first_img How to watch every Marvel Cinematic Universe film in the right order Tags 21 TV and Movies What it meansIt would seem Captain Marvel was indeed at the other end of that pager, as everyone had assumed at the end of Infinity War. It also appears Carol survived the snap. In one of the last Captain Marvel scenes, Carol gives Fury an upgraded version of his pager, telling him to use it if he ever needs her to come back.So, is this an actual scene from Avengers: Endgame, a heavily edited version of a scene, or something filmed exclusively for the Captain Marvel postcredits scene? It’s difficult to say, but I wouldn’t be surprised if this isn’t exactly how Carol’s arrival on Earth plays out in Avengers: Endgame. Nevertheless, it was awesome. captain-marvel-tv-spot-thumbCarol takes her hero shot.  Marvel Scene 2: Cute and slightly disgustingWe start the scene with a tight front shot of Nick Fury’s desk from 1995. The nameplate simply says “N. Fury” on the front. His office appears to be completely vacated. The camera slowly zooms in, and Goose the cat enters the frame. Like all cats do, especially mine — a lot lately, annoyingly — he begins to cough up a hairball. After few seconds of heaving, he coughs up the Tesseract onto Fury’s desk. After a beat, the film ends.What it meansIn the movie, Goose the cat is revealed to be a Flerken. That’s an alien species that looks like a cat but can devour things with huge tentacles that come out of its mouth. During the movie, Goose swallows the Tesseract to keep it away from Star Force — the Kree’s Seal Team 6, led by Jude Law’s Yon-Rogg, which Carol is a member of at the beginning of the movie. If only they all knew what this actually was… 26 Photoscenter_img Comments Captain Marvel is a fantastic addition to the Marvel Cinematic Universe of movies, with great performances, fantastic action, one of the best stories of any MCU movie so far and the real 90s independent movie feel. As expected, it also had two postcredits scenes. The first will probably get you even more excited about Avengers: Endgame than you already are, and the second is more of a humorous bookend to the film. Definitely stay for the first one. The second one is up to you. I will say this, though: the second one is a lot better than the second postcredits scene in Ant-man and the Wasp. And now, a huge, Quadjet-size spoiler warning if you’d rather go into the movie (and maybe Avengers: Endgame?) cold. Composite by Aaron Robinson  Scene 1: Carol Danvers, allow me to introduce you to…The scene starts with a closeup of Fury’s pager from the end of Avengers: Infinity War. It’s still beeping and Captain Marvel’s symbol is still on the screen. Suddenly the pager screen goes black. We then cut to Steve Rogers and Black Widow looking over some holographic images, still getting data on how many people are dead after Thanos’ snap. Marvel Cinematic Universe postcredits scenes, rankedRhodey then enters the room and tells them the pager is no longer sending a signal. We see Bruce Banner, who says whatever signal it was sending finally crapped out. nullCaptain Marvel just caught the train to the billion dollar club. Chuck Zlotnick/Marvel Studios “I thought we bypassed the battery,” Cap says. Replies Rhodey, “Well, we did. It’s still plugged in, just stopped.” Cap tells them to reboot it and send the signal again. Black Widow says the message was obviously important to Fury and to tell her the second they get the pager working again. “I want to know who’s on the end of that thing,” she says. Black Widow then turns to leave, and standing right in front of her is Captain Marvel looking pissed off. After a beat she asks, “Where’s Fury?” The scene ends. Share your voice Captain Marvel Marvellast_img read more

The FDA is investigating 120 cases of seizures after vaping

first_imgA man smokes an electronic cigarette inside a vape shop in Washington. Alastair Pike / AFP/Getty Images On Saturday, the Centers for Disease Control and Prevention announced that its officials are working with state health authorities to examine a growing number of pulmonary illnesses linked to e-cigarette use. But it’s not the only federal agency actively investigating vaping-related health issues.Earlier this month, the US Food and Drug Administration (FDA) announced that it has continued to look into a potential link between vaping and seizures. As of Aug. 7, the agency has received 127 reports of seizure or other neurological symptoms, such as fainting or tremors, that occurred after vaping between 2010 and 2019. That’s 92 additional cases since April 3, 2019, when the FDA issued its first statement, alerting people to the potential link. Read more: A timeline of recent Juul and vaping controversies “Although we still don’t have enough information to determine if e-cigarettes are causing these reported incidents, we believe it’s critical to keep the public updated on the information we’ve received based on the agency’s initial request for reports earlier this year,” Acting FDA Commissioner Dr. Ned Sharpless said in the latest statement.  Now playing: Watch this: Share your voice Get your vitamins by vaping 4:37 Post a commentcenter_img More than 100 cases over nine years isn’t a lot — especially compared to the total number of people using e-cigarettes — but the FDA believes cases may have gone unreported and that the potential issue warrants a scientific investigation regardless. There’s certainly a sound basis for concern: Seizures are a known potential side effect of nicotine poisoning and there have been case studies showing that people who accidentally or intentionally swallow e-liquids that contain nicotine experience seizures or seizure-like movements. juul-and-podsJuul devices are small and easy to hide from authority figures, which is likely one reason they’ve become so popular with teens. truthinitiative.org While vaporizer cartridges contain varying levels of nicotine, some e-cigarettes design features can make it easy for a user to consume high levels of nicotine quickly. For instance, Juul Labs’ Juulpods contain as much nicotine as a pack of cigarettes and the company claims its nicotine salt formulation is as easy to inhale as cigarettes and delivers nicotine up to 2.7 times faster than other e-cigarettes. Packaging can also be misleading: One study found that some e-liquids contained up to 52% more nicotine than stated. Proving a direct connection between vaping and seizures, however, has proven difficult. The reports the FDA has received haven’t provided enough detail to establish a clear pattern or cause, according to the FDA’s first statement:  “Seizures have been reported among first-time e-cigarette users and experienced users. In a few situations, e-cigarette users reported a prior history of seizure diagnosis. A few reported cases indicated that the seizures occurred in association with the use of other substances such as marijuana or amphetamines. Seizures have been reported as occurring after a few puffs or up to one day after use.”As the FDA continues its investigation, the agency is asking that consumers report any unexpected health or product issues experienced with e-cigarettes or any tobacco product to the FDA through the Safety Reporting Portal. Read more: How to quit Juuling, according to addiction expertsThe information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.  0 Tags Wellnesslast_img read more

Im alive to finish unfinished jobs of my father Hasina

first_imgAwami League president and the eldest daughter of father of the nation Bangabandhu Sheikh Mujibur Rahman speaks at a blood donation programme on the premises of Bangabandhu Bhaban at Dhanmondi Road No 32 in the capital on Wednesday. Photo: Focus BanglaReiterating that she never cares about death, Bangladesh Awami League (AL) president and prime minister Sheikh Hasina on Wednesday said she is alive to finish the unfinished jobs of her father Sheikh Mujibur Rahman, reports UNB.”I faced several blows in the past. Maybe there’ll be more but I don’t care… I never care about death. I’m alive to finish the unfinished jobs of my father, bring smile to the faces of country’s people, change their fate and give the country a dignified position in the world arena,” said Hasina.Sheikh Hasina, the eldest daughter of father of the nation Bangabandhu Sheikh Mujibur Rahman, said this while inaugurating a blood donation programme organised by Bangladesh Krishak League on the premises of Bangabandhu Bhaban at Dhanmondi Road No 32.Hasina said the debt of Bangabandhu’s blood could be paid through building the country as ‘Golden Bangladesh’ as he had dreamt. “We’ve to pay his blood debt…we’ll be able to pay his debt of blood by building the country as Golden Bangladesh. InshaAllah, we’ll be able to do that; I have that belief,” she said.She said the country has already made a good progress in its journey towards its goal of being ‘Golden Bangladesh’. “We’ll advance the country further.”Sheikh Hasina, also the chief of ruling Awami League, sought cooperation of people in maintaining the pace of development that the country attained in the last nine and a half years.”We want you to pray for us… the pace of development we’ve attained must not be stopped. We can fulfill Father of the Nation’s dream of ‘Golden Bangladesh’ through maintaining the pace of progress,” she said.The prime minister firmly said she can say that Bangladesh now got a dignified position in the world and the country is now a developing one. “Surely, the souls of my father, mother and millions of martyrs will get peace,” she added.Recalling the horrible memories of 15 August 1975, she said the defeated force of 1971 and freedom fighters by chance who never contain the spirit of the Liberation War were the mastermind of this massacre. “The defeated force took their revenge through killing the Father of the Nation,” she said.Sheikh Hasina mentioned that the killers thought that the existence of Bangladesh would be vanished with the killing the father of the nation.She said the government has been able to put the killers of Bangabandhu under trial and implement the court verdict. “Still, there’re some killers hiding in various countries. We’re trying to bring them home,” she said.Hasina alleged that the self-claimed and convicted killers mentioned that they had communication with Ziaur Rahman and they had informed him about the killing. “Zia told them to go ahead, and said if they become successful he is with them,” she said.She said Ziaur Rahman awarded the killers by appointing them in different missions. “Why did he give them award? He was fully involved in the killing. That’s why he gave them award,” she said.Sheikh Hasina also said the consequence of Ziaur Rahman was inevitable for him. “My sorrow is that I couldn’t put him under trial. He passed away before that,” she added.last_img read more

100000 migrants fled to wartorn Yemen in 2017 IOM

first_imgChildren look at destruction in a petrol station following an air strike on the outskirts the Yemeni rebel stronghold of Saada in the Huthi movement`s northern heartland on 7 May, 2018. Photo: AFPNearly 100,000 migrants fled last year to Yemen, itself gripped by war and impending famine, to escape poverty and violence at home, the International Organization for Migration said Tuesday.Some 7,000 migrants entered Yemen each month, with the total number of arrivals in 2017 reaching near 100,000, the IOM said.Fleeing violence and poverty in the Horn of Africa, and at the mercy of smugglers, they hope to ultimately reach the more prosperous Gulf countries.Yemen is bordered to the north by Saudi Arabia.Once in Yemen — where nearly 10,000 people have been killed in three years of war — the lucky ones find “irregular work”, the IOM said.Less fortunate migrants face torture, sexual abuse and death.”Both en route and once in Yemen, many migrants suffer at the hands of cruel smugglers and other criminals, including physical and sexual abuse, torture for ransom, arbitrary detention for long periods of time, forced labour for no pay and even death,” the IOM said.Human Rights Watch last month released a report documenting Yemeni government employees who had “tortured, raped, and executed” migrants and asylum seekers at the Buraika migrant detention facility in the southern province of Aden, where the country’s embattled government is based.Migrants held at the facility — in use since early 2017 — were denied refugee protection and often deported en masse into rough seas, the watchdog said.The United Nations refugee agency has corroborated the report.Scores of migrants from Somalia and Ethiopia have died off the coast of Yemen in recent months.Last summer, dozens of migrants drowned after human traffickers forced them off their boats and into the sea. In January, more than 30 migrants drowned when their boat capsized off the Yemeni coast.In March 2017, a helicopter opened fire on a vessel carrying more than 140 migrants in the Red Sea off the Yemeni coast, killing 42 civilians.A confidential UN report seen by AFP said the attack was most likely carried out by the Saudi-led coalition, which is fighting alongside the Yemeni government against the country’s northern Huthi rebels, who are linked to Iran.The conflict has unleashed what the UN has called the world’s worst humanitarian crisis.last_img

Iron rods go through masons body as he falls from roof finds

first_imgKolkata: Three iron rods pierced the body of a mason after he fell from the roof of an under-construction building at Champahati area of Baruipur in the South 24-Parganas district on Wednesday morning.The victim, identified as Uday Sardar, was immediately taken to the Baruipur Super-Specialty Hospital by the local people. The doctors in the hospital did not want to take any risk as the patient still had the three iron rods that had gone through the right side of his abdomen. Also Read – Rain batters Kolkata, cripples normal lifeThe victim was then taken to Calcutta National Medical College and Hospital (CNMCH), where a digital x-ray was performed on the patient. It was not easy for the technicians to carry out the x-ray as he had to be kept in a seated posture.The doctors at CNMCH successfully removed the three rods from his body, following a critical surgery that lasted for hours. The patient, however, is still stated to be in a critical condition due to the severe nature of his injuries. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedAfter examining the reports, the doctors at the hospital found that one rod was located near his kidney, while another was close to his intestine. The third one was below his liver.The hospital authorities felt the need of an emergency surgery but there were many challenges before them.A medical board has been formed, comprising 7 doctors including the head of the department of general surgery and the heads of the Orthopedic department, Cardiothorasic department, Neuro surgery and Urology department of the hospital. The medical board was in a fix as the iron rods were nearly 3 feet long. The main concern for the doctors was removing the rods as it could make the patient bleed to death.Senior PWD engineers were asked to rush to the hospital and see if they could make the rods shorter in length by cutting them from both ends, as it would have been extremely difficult for the doctors to remove the rods otherwise.The PWD engineers, however, told the doctors that cutting the rods which had already pierced his body, might damage the organs due to the vibration which will be created.The medical board later started the operation on Wednesday evening, with the PWD engineers inside the OT. A huge quantity of blood was arranged by the hospital authorities before starting the operation.A senior official of the hospital said that the iron rods have been removed successfully.last_img read more

Drawing a unique connect Hills celebrate Tiwar with religious fervour

first_imgDarjeeling: The unique festival of “Tiwar” commenced with “Kak Tiwar” on Monday in Darjeeling and Kalimpong.Dipawali is celebrated in a unique way in Darjeeling. The 5 days of “Tiwar” or “Yamapanchak,” is commemorated in the honour of “Yamraj” — the mythological Lord of Death. The first day of Tiwar is Kak Tiwar, dedicated to the crows, believed to be the bird associated with Yamraj. On this day food is left on rooftops and open spaces for the crows. Also Read – Rain batters Kolkata, cripples normal lifeThe next day is Kukur Tiwar. On this day marigold garlands are put on dogs with vermillion being applied on the forehead of dogs. The dog is offered a sumptuous meal. Even stray dogs are not left out on this day and people offer food to them as well. The third day of Tiwar, which falls on the day of Dipawali, is commemorated as Gai Tiwar. Early in the morning, the cows which symbolise goddess Lakshmi are worshipped. The houses are painted and marigold garlands are put on doors to welcome Goddess Lakshmi. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedIn the evening after Lakshmi Puja, tika is annointed on the forehead of seven small girls as they are worshipped as the forms of Lakshmi. Diya or lamp is lit in the main altar of the house. Along with the diyas, copper vase called Gagri is kept filled with water and decorated with flowers. Several groups of girls dressed in traditional Gunue Cholo sit outside the main entrance of houses and sing the traditional “Bhailo.” The next day of Gai Tiwar or Laxmi Puja is the Goru Tiwar — the day dedicated to the ox. In the evening “Deushi” is sung by groups of boys wearing traditional “Daura Suruwal” and playing traditional musical instruments, madal, chyabrung and jhyamta. The five-day Tiwar concludes with “Bhai-Tika.” Both Bhailo and Deushi are forms of folk culture. Both have got a common mythological background. According to mythology, during the Satya Yug, Lord Vishnu in the form of a dwarf had asked for alms from King Bali. King Bali was renowned for his charitable nature. Keeping his word, King Bali gave away his kingdom to Lord Vishnu. The girls of his kingdom fearing destruction, in groups, prayed to Goddess Lakshmi to bestow the kingdom with riches so that its lost glory could be regained. “I do not usually return home during Dussehra but try my best to get leaves for Tiwar. The festival is fun-filled and I love playing Deusi with my friends. It’s also about a sumptuous traditional spread including “Sel Roti” (traditional sweet bread) and different types of “Aachar”, stated Avisekh Bagdas who works in Delhi.last_img read more

Ericsson has launched its MediaFirst Video Deliver

first_imgEricsson has launched its MediaFirst Video Delivery solution – the latest addition to the Ericsson MediaFirst portfolio.Ericsson said the solution is a response to the “increased volumes of video traffic over operator networks”, with the release following the launch of Ericsson MediaFirst Video Processing at NAB earlier this year.The modular video distribution platform is designed to let service providers and broadcasters enhance the distribution of managed video services to mobile devices.The solution uses modern content delivery network (CDN) technology to deliver adaptive live TV, video on demand, cloud DVR and time shifted content.Ericsson said it enables IPTV, cable and mobile operators to “handle managed and unmanaged content by enhancing their network efficiencies and reducing associated costs.”“With ever increasing volumes of video traffic being consumed, operators require complete content visibility and control throughout the entire delivery chain in order to differentiate their multiscreen OTT services,” said Ericsson’s head of media delivery, Carlos Gonzalez.“Mobile video traffic is forecast to grow by around 55% annually through to 2021, when it should account for over two-thirds of all mobile data traffic. This underlines the need for next-generation cloud based solutions to deliver a superior performance.”Ericsson launched the MediaFirst Video Delivery solution at the Broadcast Asia 2016 event in Singapore.last_img read more

UltraViolet the initiative that gives users digit

first_imgUltraViolet, the initiative that gives users digital access to movies and TV series they’ve purchased, is due to shut down on July 31.According to information posted on the UltraViolet website, the move is due to “market factors” – including the emergence of  content services separate to UltraViolet.“In most cases, your movies and TV shows will be available via the retailers linked to your UltraViolet Library at the time of UltraViolet shutdown,” said UltraViolet.“While there could be some disruption, we do not anticipate this on a broad scale and are working diligently to minimise and avoid such instances.”UltraViolet said it is working with UltraViolet retailers – which include services like Vudu, Flixster and Kaleidescape – to maximise users’ continued access to movies and TV shows.However, users’ UltraViolet Libraries will be automatically closed after UltraViolet shuts down.A consortium of film studios, consumer electronics manufacturers and retailers called the Digital Entertainment Content Ecosystem (DECE) launched UltraViolet in the US and UK in 2011.UltraViolet users can redeem codes bundled with physical Blu-ray and DVD purchases to access the content digitally. The scheme was also designed to unify customers’ digital purchases in a single location.The scheme was supported by the likes of Sony Pictures Entertainment, Warner Bros, Lionsgate and NBCUniversal, but never gained the backing of Disney, which went its own way with its Disney Movies Anywhere service.Amazon, Google and Apple were also key players that did not join DECE or support UltraViolet.last_img read more

•  Investors like MLPs because of their high yield

first_img •  Investors like MLPs because of their high yields… Regular readers know that the Federal Reserve cut its key interest rate to zero in 2008. It’s left it there ever since. This pushed interest rates to ridiculously low levels, making it difficult for investors to earn a decent yield. Take the 10-year Treasury, for example. In 2007, its yield averaged 4.63%. Today, it yields just 2.05%. From the beginning of 2009 through June 2014 (when energy prices peaked), AMZ returned 294%. Meanwhile, the S&P 500 returned just 110%. One big reason for AMZ’s great performance is that MLPs were one of the only investments where investors could earn a decent yield. Many investors bought MLPs thinking they were safe ways to invest in America’s booming energy sector. After all, MLPs were supposed to earn steady income streams that didn’t depend on the price of oil, natural gas, or coal… Earlier this year, The Wall Street Journal explained why MLPs are supposed to be insulated from volatile energy prices. To manage swings in fuel prices, the partnerships have contracts that guarantee them minimum prices for oil and gas. Such contracts, or hedges, will help them weather lower prices in the near term. In the same article, The Wall Street Journal noted that many of those hedges expired in 2015. That’s been a big problem. The price of oil has fallen 48% over the past year. And the price of natural gas has fallen 39%. Many MLPs are now exposed to these weak prices. And it’s starting to show up on their income statements: Energy Transfer Partners (ETP) is a pipeline MLP worth $22 billion. The company’s quarterly revenues fell by an average of 43% during the first two quarters of 2015. Last year, the company averaged 13% quarterly revenue growth during the first and second quarters. Magellan Midstream Partners (MMP) is a pipeline MLP worth $16 billion. Its quarterly revenues dropped 9% during the first and second quarters of 2015. Last year, the company’s revenues increased 27% on average during the same two quarters. MarkWest Energy Partners (MWE) is another pipeline MLP. It’s worth $9 billion. Its quarterly revenues fell by 10% on average during the first two quarters of 2015. Last year, the company’s revenues increased 31% on average during the first two quarter. •  MLPs have crashed with the rest of the energy market… The chart below shows the performance of AMZ over the past year. As you can see, it’s down 36% in just twelve months. Regards, Justin Spittler Delray Beach, Florida October 06, 2015 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful. – Urgent Announcement: Banking Insider Warns: “If you were born before 1969, you should move 20% of your savings here now.” More than 60,000 Americans are now following “Ronald Reagan’s Secret Retirement Income Plan,” and moving their money out of the traditional financial system into one little-known safe haven where wealth grows tax-free… This 100% legal “tax shelter” has proven—over 232 years—to protect and grow wealth in times of recession, depression, inflation, and even dollar weakness.  Joe Biden, Hillary Clinton, and at least 52 other Washington officials have already moved a portions of their cash here…  The big banks have already moved $143 billion here… and plan to move billions more. Now, you can find out all the details for FREE. Click here to claim your free starter kit. The “toll takers” of the energy industry have crashed… The Alerian MLP Index (AMZ) lost 22% last quarter. It was the index’s worst quarter ever. AMZ lost an incredible 15% in September alone. AMZ tracks 50 of the biggest master-limited partnerships, or MLPs. Most MLPs act as “toll roads” for the energy sector. Natural gas pipeline companies are a common type of MLP. Unlike natural gas producers that look for natural gas and pull it out of the ground, a pipeline MLP helps move natural gas from one place to another. These companies typically charge a set fee for each cubic foot of gas they transport, regardless of the price of natural gas. MLPs trade on public stock exchanges, but they’re a little different from most stocks. They don’t pay corporate taxes. And they have to distribute nearly all of their income to investors. Because of this unique structure, MLPs generally pay high yields. AMZ currently yields 7.99%. Meanwhile, the S&P 500 yields just 2.25%. •  The market for MLPs has exploded in recent years… The number of MLPs jumped from 32 in 2003 to over 100 last year. And between 2008 and 2014, the value of the MLP industry jumped from under $100 billion to over $500 billion. America’s booming energy market helped fuel this explosive growth. Regular readers know that U.S. oil production has more than doubled over the past six years. U.S. natural gas production also jumped 40% between 2004 and 2014. More oil and natural gas production means more oil and natural gas must be processed, transported, and stored…which benefits MLPs. Recommended Links Doug Casey Issues Warning to America From His Secluded 1,235 Acre Farm: “This is a very bad situation. The U.S. is digging itself in deeper and deeper.” Click here to learn more. — A big reason for the selling is that investors are worried MLPs will cut their payouts. So far, that hasn’t happened… Not one midstream MLP cut its distribution from the beginning of 2014 through the second quarter of 2015. In fact, the 25 midstream MLPs tracked by the index actually raised distributions a total of 111 times during that timeframe. • But that doesn’t mean you should buy MLPs… E.B. Tucker, editor of The Casey Report explains why MLPs are dangerous: Many investors blindly buy MLPs for their rich yields without understanding what they’re buying… MLPs are legally required to pay out at least 90% of their profits to investors. After MLPs pay investors, there’s almost no money left to invest back in the business. That means MLPs have only two options when they need money to pay for repairs, maintenance, and upgrades. They can issue new stock, or they can raise money by selling bonds. Neither option is attractive for MLP investors. The bond market doesn’t want to loan MLPs money right now. MLPs that desperately needs cash are going to pay out the nose to get it. The only other choice is to issue more shares…which reduces the value of existing shares. Chart of the Day MLPs pay some of the highest yields in the market… Today’s chart compares AMZ’s yield to other types of investments. As you can see, MLPs pay roughly triple what stocks in the S&P 500 and Dow Jones Industrial Average (DJIA) yield. MLPs also pay twice as much as real estate investment trusts (REITs) and utilities. However, this doesn’t mean MLPs are a good investment. As we explained earlier, MLPs have several problems including falling revenues and a lack of good financing options. We don’t recommend buying MLPs as a group at today’s prices.last_img read more

Two groups have been chosen to set up new centres

first_imgTwo groups have been chosen to set up new centres for independent living (CIL) in Wales, doubling the number of CILs in the country.The new centres will be located in Ceredigion, in the west of the country, and Flintshire, in the north, and will both be run and controlled by disabled people.Although there are only two existing CILs in Wales, the long-term aim is to have one in every one of its 22 counties.The two new CILs were selected by Disability Wales, the Wales Co-operative Centre (WCC), and Dewis Centre for Independent Living, as part of the £318,000 Welsh government-funded Enabling Wales programme.Disability Wales said it hoped they would provide “a kick start to developing more CILs across Wales”.The two groups will now receive support from Disability Wales, WCC and Dewis CIL as they work towards opening their doors to disabled people next March.That support will include help with the bids they will need to make to local authorities, the Welsh government and other sources of funding to allow them to meet their running costs.Disability Wales said the two groups would need to “strike a balance between their traditional campaigning role… with the need to operate successfully within a highly competitive commercial environment, and to manage the potential conflicts of interest when delivering public contracts”.The Ceredigion CIL will focus on providing information and advice – including disability equality training; self-advocacy; offering support to victims of hate crime; campaigning; and fundraising – and will be run by the disabled people’s organisation Disabled People Together, as well as the non-user-led groups Mencap Ceredigion and Creative Lifestyle Solutions.Rhiannon Hicks, Enabling Wales project officer at Disability Wales, said: “The Ceredigion group were successful as they showed a strong understanding of organisations led by disabled people for disabled people.“They also have a strong commitment to the social model of disability, as well as good partnerships with relevant third sector bodies.”The Flintshire CIL will be run by the user-led Flintshire Disability Forum (FDF), and will provide services such as help with managing personal budgets; campaigning; recruitment and training of personal assistants; assistance completing application forms; and equipment hire.Hicks said: “The FDF were successful as they have a strong track record of project delivery, and of securing funding. They also have strong partnerships.”She added: “I very much look forward to working with both groups in the next stage of the project.”Rhian Davies (pictured), director of Disability Wales, said: “We are delighted that following an 18-month long programme of training, development and coaching, working with 65 disabled people across Wales, we have achieved our goal in being able to select two emerging CILs and support their development over the remainder of the Enabling Wales project.“CILs are social enterprises that deliver services run by disabled people for disabled people and offer a new and creative model of provision in line with what people actually need to achieve independent living and well-being as well as maximise scarce resources.”Disability Wales said it hoped the new organisations would in time be able to support other groups towards becoming CILs, while it would itself be providing a “tool kit” on how to set up a CIL.Carl Sargeant, the Welsh government’s cabinet secretary for communities and children, congratulated the two groups, and said: “I am sure that, with the support of the Wales Cooperative Centre and Dewis CIL, they will develop and grow into sustainable enterprises which will promote independent living for disabled people and provide them with the services they need to support their well-being.”Picture by Natasha Hirstlast_img read more

The government wants to increase the number of peo

first_imgThe government wants to increase the number of people who use personal health budgets (PHBs) to choose their own health and social care support from 40,000 to as many as 200,000 over the next five years.It hasapproved extending legal rights to PHBs to disabled people eligible for fundingfrom NHS wheelchair services, and those eligible for aftercare services undersection 117 of the Mental Health Act.But it alsosignalled that these rights would eventually be extended to other groups,including people with ongoing social care needs who also make regular andcontinuing use of particular NHS services; people leaving the armed services whoare eligible for ongoing NHS services; and autistic people and those withlearning difficulties who are eligible for ongoing NHS care.PHBs giveindividuals a pot of money to spend on their health and wellbeing needs, inagreement with a healthcare professional.Manydisabled campaigners have supported the expansion of PHBs, arguing that theycould help deliver independent living for disabled people, whileothers have raised concerns that they could be part of a creepingprivatisation of the NHS, and that they are based on the same “failing” modelused with social care personal budgets.Currently,only adults receiving NHS Continuing Healthcare, and children and young peoplewho receive continuing care, have the right to a PHB.But the Department of Health and Social Care (DHSC, pictured) and NHS England have now published their response to a consultation, which ended last June, on extending that right to other groups and the possibility of extending that to include a right to have the PHB managed through direct payments.The governmentresponse says people “value being involved in the planning of their care, beingable to make choices and personalise their support so it best meets their needs”.And it saysthe evidence suggests that those who can do that “are more satisfied with theircare, have better outcomes, and are able to explore more innovative approachesto meet their needs”.Theconsultation also asked for views on whether the government should bringtogether PHBs and social care personal budgets – and educational needs in thecase of disabled children and young people – into an integrated personalbudget.Theconsultation results suggested widespread support for a further expansion of PHBs,with 87 per cent (330 of 379 people) of those who answered the question sayingthey believed that autistic people and those with learning difficulties who areeligible for ongoing NHS care should have a legal right to a PHB or anintegrated personal budget.And morethan 90 per cent supported extending the right to a PHB or integrated personalbudget to those using NHS wheelchair services, with 87 per cent saying thisgroup should also have a right to receive that budget via direct payments, ifappropriate.DHSC and NHSEngland said their ambition was “to move towards joined up and integratedprovision across health and social care” through a “comprehensive model ofintegrated, personalised care” and with PHBs and integrated personal budgets “akey component” of this plan.These plansare set out in the new NHS LongTerm Plan.Thegovernment and NHS England said they believed that more than 200,000 people wouldhave a PHB by 2023-24, including many from the five groups they consulted onlast year.Although thegovernment is only taking forward legislation on those using wheelchairservices and mental health aftercare, it says it will “continue to furtherexplore both the other groups we consulted on, and additional groups who webelieve could also benefit from having a right to have a personal health budget”.Someadditional groups that could benefit and were mentioned by those taking part inthe consultation included people with dementia, people receiving end-of-lifecare, and those receiving community equipment.NHS Englandsaid it would continue to work with clinical commissioning groups to “designand test” the use of PHBs for other groups of people and service areas.Careminister Caroline Dinenage said: “I’ve seen first-hand how personal health budgets can givepeople a new lease of life, granting them the ability to enjoy their lives tothe full. “Thesebudgets help to join up health and social care services, improving people’sexperiences and outcomes whilst ensuring value for money for taxpayers.“We are therefore extending access so many more people can benefit, a key part of our NHS Long Term Plan which will see personalised care become the norm for millions more.”A note from the editor:Please consider making a voluntary financial contribution to support the work of DNS and allow it to continue producing independent, carefully-researched news stories that focus on the lives and rights of disabled people and their user-led organisations. Please do not contribute if you cannot afford to do so, and please note that DNS is not a charity. It is run and owned by disabled journalist John Pring and has been from its launch in April 2009. Thank you for anything you can do to support the work of DNS…last_img read more

Marketers Shouldnt Have to be Data Scientists

first_imgOver the past decade, the rise of Data-Driven Marketing and Account-Based Marketing (ABM) have both followed steep trajectories, and that’s no coincidence. After all, the best ABM programs are the ones built on rich data and insights. However, the meteoric rise of data-fueled ABM has had an unintended side effect inside the marketing organization: Marketers now have to become data experts or hire them in droves.As the complexity of analyzing and employing data for ABM increased, marketers started to get lost in the numbers. While building B2B marketing teams with greater data-savvy and talent is a wise move, Marketing Executives must be careful not to overcorrect when it comes to rebalancing the skill sets within their organizations. Furthermore, they must ensure that the data talent they do have in-house is being effectively leveraged, rather than wasted on mundane data organization tasks.The simple fact is that data solutions exist within the market that can greatly simplify the process of combining sources, deriving insights and putting those insights to work in campaigns. B2B marketers should not have to become Data Scientists, and the Data Scientists they work with should be spending their time delivering real value to the bottom line. To do this, teams need to be armed with data tools that allow them to do what they do best: draw insights, build relationships and tell the right stories to the right people.Read More: Think Before the Ad using Customer DataMoving from Data to InsightsA 2018 Gartner report made a simple yet profound observation: ‘Marketing departments have staffed up their data analytics teams who spend more time wrangling data than building insights’. The report went on to recommend that marketing executives rethink their allocation of resources in this regard. ‘Strategic outsourcing and automation start to make sense when a significant volume of foundational tasks are currently handled by talented, expensive (and coveted) data scientists’, the report noted.Of course, there are numerous external resources available to marketing teams that can assist with the foundational work that is needed to wrangle multiple data sources and put teams on the path to true insights and optimization. In finding the right fit, marketing leaders need to ensure a resource’s capabilities complement that of their internal teams and enable them to focus on the tasks that lead to success with ABM. Core requirements include the following.Diverse data sources that enable hyper-targeting. ABM teams have a deep need to understand not only who their prospects are, but where they are on their buyer journey. As such, Data Optimization Solutions need to tap into a diverse range of data sources—from firmographic and technographic data to audience and intent. Only with this diversity of sources can marketers begin to understand who their strongest prospects are, what they’re in the market for, where they are based and when to reach out via marketing and sales channels.Insights that drive action: The right data solution should also be able to feed learning back into the system for refinement, otherwise data teams have to spend their valuable time doing this in a piecemeal way. Through enhanced insights dashboards, marketers should be able to track a campaign’s progress across channels, see who engages with what content and discern which programs have the greatest sales impact. From there, they can take action to close their best accounts faster.Read More: Social Media vs. Messaging Apps: What Brand Marketers Need to KnowAcceleration of the customer journey: As Gartner noted, the strategic use of automation within the Data Optimization process represents a path to greater efficiency for marketing and data teams. Data Solutions should be capable of automatically moving prospects along the customer journey by shifting them into the proper media and content programs based on their engagement and demonstrated interests. The right data automation can significantly reduce manual tasks and achieve better conversion by continuously engaging prospects with relevant content to keep them moving down the pipeline.As B2B marketers realign the way that they use data to prospect and engage, they must do so with an eye toward making the most of their internal resources. As Gartner noted, some expensive data talent too often ‘spend their time doing work that is necessary but not necessarily the work that will drive competitive differentiation and breakthrough insights’. There is a better way. With the right Data Optimization tools, marketers can focus on building true Business Intelligence to drive more efficient, effective outreach across all channels.Read More: Customer Lifetime Value (CLV): the MVP of Your Marketing Metrics ABMB2B Marketingdata analyticsData Optimizationdata scientistsGartnerintent dataMadison LogicMarketing Previous ArticleLatentView Analytics Launches AI-Driven Conversational Analytics Platform ‘Casper’ to Democratize Enterprise DataNext ArticleUnmetric Integrates AI-Driven Social Media Benchmarking Solution into Hootsuite Marketers Shouldn’t Have to be Data Scientists Tom O’ReganJune 6, 2019, 3:00 pmJune 6, 2019 last_img read more

OOH Advertising Solution Provider Quorum Leverages Quadrants Filtered Authenticated Location Data to

first_img Marketing Technology NewsNewsOOH advertisingout-of-home advertising solutionQuadrantQuorum Previous ArticlePFL Hosts Ribbon Cutting Ceremony to Celebrate New Digital Production & Fulfillment CenterNext ArticleAtento Opens a New Customer Relationship Center in Madrid Quadrant’s High Volume Location Data Sets Stamped with Blockchain-Enabled Authentication Technology Giving Quorum Unprecedented ‘Hyperlocal’ Targeting Ability Throughout Entire Consumer Journey Quadrant, the platform that maps and authenticates data making it easier to buy and sell quality, authentic data feeds, announced that it is providing out-of-home (OOH) advertising solution provider Quorum with authenticated, filtered location data to accurately target the consumer in motion. Quadrant supplies Quorum with location data that is accurate, at scale and contains the right type of data, strengthening Quorum’s ability to execute, link, measure and analyse OOH advertising to wider marketing campaigns.Quadrant’s high-volume location data, which includes time, date, location and anonymous ID’s of consumer mobile devices, is stamped with blockchain-enabled data authentication technology ensuring accuracy as at the time of stamping. This data, which originates from multiple sources, is filtered to ensure that only the most relevant points are delivered to Quorum, who in turn processes it through its own algorithm to identify consumers who have passed specific billboards and visited other specific Points of Interest (POI). By integrating this level of precise, authentic location data, Quorum enables advertisers to more deeply understand the customer journey – to and from where they are travelling and when – and to target those consumers with a more strategic and customized approach. Marketing Technology News: New ISG Study Focuses on Digital Business Services“Quadrant’s data allows Quorum to offer much more relevant and accurate targeting solutions for its clients” says Mike Davie, CEO of Quadrant. “Quadrant’s Data as a Service (DaaS) model makes it easier for Quorum to find and use large location data sets. This allows advertisers to plan and execute mobile companion advertising campaigns in coordination with their outdoor programs, giving them accuracy at a lower cost, and therefore better ROI.”Marketing Technology News: ada Strengthens Its Leadership Team as It Doubles Its Headcount“We deliver a ‘one-two’ effect for clients who want to follow up on the awareness generated by a billboard or other outdoor placement with a response-focused mobile advertisement, and a new form of analytics that converges data points from both the outdoor and mobile media channels,” says Ezra Doty, CEO and Co-Founder at Quorum. “By tapping Quadrant’s refined location data, Quorum is able to expand its platform’s reach and accuracy. The filtered data that Quadrant provides is well suited for our needs and allows us to feed it into our own algorithms to generate highly accurate results.”Marketing Technology News: SeQuel Response Hires New Director of Marketing to Propel Brand Awareness OOH Advertising Solution Provider Quorum Leverages Quadrant’s Filtered, Authenticated Location Data to Reach Consumer in Motion with Accuracy and Scalability MTS Staff Writer6 days agoJuly 12, 2019 last_img read more

New technology could change the way gene editing is approached in future

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 4 2019Gene editing has been a much sought after and controversial technology. Last month, part of the World Health Organization called for an international registry to track all research into editing the human genome.Purdue University researchers, including one who was inspired by the cancer death of a close friend, have developed a new technology that could change how gene editing is approached in the future. The research team presents the work on April 4 at the National Meeting of the American Chemical Society in Orlando.One of the most widely used methods for gene editing is CRISPR-Cas9 technology. The method requires a certain sequence or motif for function that restricts modifications.”CRISPR can be programmed to cut DNA at specific regions to make precise edits in an organism that can increase sustainable manufacturing, treat disease and even create better crops,” said Kevin Solomon, an assistant professor of agricultural and biological engineering, who leads the Purdue research team. “However, it requires a certain sequence for function that restricts modifications to certain regions.”Related StoriesMother calls for protein shake regulation after daughter diesEMBL study reveals uncoupling between chromatin topology and gene expressionResearchers discover gene linked to healthy aging in wormsMany diseases in humans, including several types of cancer, are caused by mutations at specific sites in the genome. The Purdue team created a method that uses the protein Argonaute from Natronobacterium gregoryi (NgAgo) and supplied DNA as a guide to enable modification anywhere on the genome, providing new options to potentially improve manufacturing, disease treatment, drug discovery and crop production.”While there is still work to do, we have shown that these molecular scissors can edit regions of DNA previously inaccessible by current technologies,” said 2nd Lt. Michael Mechikoff, a master’s student working on the project.”One of my best friends died from a cancer caused by a genetic variant several years ago,” said Kok Zhi Lee, a doctoral student who works on the research team in Solomon’s lab. “I always dreamed of a different scenario for my friend – living in an era where genetic engineering is a regular and safe option to correct genetic disorders. With the potential of our technology, I anticipate a future where genetic disease is history for human beings.”The team has worked with the Purdue Research Foundation Office of Technology Commercialization to file a utility patent on the technology. They are looking for partners and others interested in developing and licensing it.Their work aligns with Purdue’s Giant Leaps celebration, acknowledging the university’s global advancements in health as part of Purdue’s 150th anniversary. It is one of the four themes of the yearlong celebration’s Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.Source: https://www.purdue.edu/last_img read more

CGM evaluations in longterm islet transplant recipients show nearnormal glycemic profiles

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 10 2019Continuous glucose monitoring (CGM) evaluations in islet transplant recipients who have been insulin independent for an average of 10 years show near-normal glycemic profiles and time-in-range metrics, according to data presented by the Diabetes Research Institute at the University of Miami Miller School of Medicine.The findings, which were accepted as a late-breaking poster at the American Diabetes Association (ADA) 79th Scientific Sessions, June 7 – 11, 2019 in San Francisco, CA, demonstrate that islet transplantation can be a successful long-term cell therapy for select patients with type 1 diabetes.The DRI team evaluated five of its adult subjects who received intrahepatic (in the liver) islet transplants between 2002 – 2010 and have since remained insulin independent for seven to 16+ years. During their last study follow-up, the subjects completed a 7-day, non-blinded CGM to assess their glycemic profiles.Compared to current recommended CGM goals for adults with type 1 diabetes on a hybrid closed-loop system, all patients demonstrated improved CGM time-in-range, reduction in glucose variability, and prevention of hypoglycemia. A sampling of the results is as follows:In addition, time in the more stringent glucose range of 70-140 mg/dL was 83.1%, with a mean sensor glucose (SG) value of 116 mg/dL and an average HbA1c of 5.7%. The ADA’s recommended HbA1c goal is <7% for adults with diabetes. Using continuous glucose monitoring, we now have the ability to accurately evaluate patients' glucose profiles and their variability. The CGM data we have obtained from our islet transplant patients clearly demonstrates that islet transplantation can result in glucose levels that are close to those in people who do not have type 1 diabetes, even 10 years or more after undergoing the cell-replacement procedure."David Baidal, M.D., assistant professor of medicine and member of the DRI's Clinical Islet Transplant Program One of the principal investigators of the study, Dr. Baidal is presenting the results at the ADA conference."Although not all subjects remain insulin independent, like the subjects described in this presentation, after an islet transplant a significant number of them continue with excellent graft function for over 10 years that allows them to have near-normal glucose metabolism in the absence of severe hypoglycemia on small doses of insulin," said Rodolfo Alejandro, M.D., director of the Clinical Cell Transplant Program and also a principal investigator of the study. Dr. Alejandro will be presenting these results at the upcoming 17th World Congress of the International Pancreas & Islet Transplant Association, July 2-5, 2019 in Lyon, France.Related StoriesImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsALS mobility and survival could be improved by increasing glucoseHigh-fat, low-carbohydrate diet may improve brain function and memory in older adults"This report confirms the superiority of transplantation of insulin-producing cells compared to insulin therapy, with glucose control results that were even better than the goals of CGM in hybrid closed-loop systems. Hopefully, this will be of assistance in bringing islet transplantation closer to FDA approval, allowing the treatment to be made available to U.S. patients, as has already been the case in several other countries, for many years," said Camillo Ricordi, M.D., Stacy Joy Goodman Professor of Surgery and director of the Diabetes Research Institute, who was recently named the world's leading expert in islet transplantation by Expertscape. Dr. Ricordi is well-known for inventing the machine (Ricordi Chamber) that made it possible to isolate large numbers of islet cells from the human pancreas and for performing the first series of successful clinical islet transplants that reversed diabetes after implantation of donor purified islets into the liver of recipients with diabetes.In type 1 diabetes, the insulin-producing islets cells of the pancreas have been mistakenly destroyed by the immune system, requiring patients to manage their blood sugar levels through a daily regimen of insulin therapy.Islet transplantation has allowed some patients to live without the need for insulin injections after receiving a transplant of donor cells. Some patients who have received islet transplants have been insulin independent for more than a decade, as DRI researchers have published. Currently, islet transplantation remains an experimental procedure limited to a select group of adult patients with type 1 diabetes.In 2016, the National Institutes of Health-sponsored Clinical Islet Transplantation Consortium reported results from its Food and Drug Administration (FDA)-authorized Phase 3 multi-center trial, of which the DRI was a part, indicating that islet transplantation was effective in preventing severe hypoglycemia (low blood sugar levels), a particularly feared complication in type 1 diabetes that can lead to seizures, loss of consciousness and even death.The study was a significant step toward making islet transplantation an approved treatment for people with type 1 diabetes and reimbursable through health insurance, as it is in several other countries around the world.center_img Source:Diabetes Research Institute Foundationlast_img read more

FDA approves new drug to treat hypoactive sexual desire disorder in premenopausal

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 23 2019The U.S. Food and Drug Administration today approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. There are women who, for no known reason, have reduced sexual desire that causes marked distress, and who can benefit from safe and effective pharmacologic treatment. Today’s approval provides women with another treatment option for this condition. As part of the FDA’s commitment to protect and advance the health of women, we’ll continue to support the development of safe and effective treatments for female sexual dysfunction.”Hylton V. Joffe, M.D., M.M.Sc., director of the Center for Drug Evaluation and Research’s Division of Bone, Reproductive and Urologic Products HSDD is characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to a co-existing medical or psychiatric condition, problems within the relationship or the effects of a medication or other drug substance. Acquired HSDD develops in a patient who previously experienced no problems with sexual desire. Generalized HSDD refers to HSDD that occurs regardless of the type of sexual activity, situation or partner.Vyleesi activates melanocortin receptors, but the mechanism by which it improves sexual desire and related distress is unknown. Patients inject Vyleesi under the skin of the abdomen or thigh at least 45 minutes before anticipated sexual activity and may decide the optimal time to use Vyleesi based on how they experience the duration of benefit and any side effects, such as nausea. Patients should not use more than one dose within 24 hours or more than eight doses per month. Patients should discontinue treatment after eight weeks if they do not report an improvement in sexual desire and associated distress.The effectiveness and safety of Vyleesi were studied in two 24-week, randomized, double-blind, placebo-controlled trials in 1,247 premenopausal women with acquired, generalized HSDD. Most patients used Vyleesi two or three times per month and no more than once a week. In these trials, about 25% of patients treated with Vyleesi had an increase of 1.2 or more in their sexual desire score (scored on a range of 1.2 to 6.0, with higher scores indicating greater sexual desire) compared to about 17% of those who took placebo. Additionally, about 35% of the patients treated with Vyleesi had a decrease of one or more in their distress score (scored on a range of zero to four, with higher scores indicating greater distress from low sexual desire) compared to about 31% of those who took placebo. There was no difference between treatment groups in the change from the start of the study to end of the study in the number of satisfying sexual events. Vyleesi does not enhance sexual performance.Related StoriesTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTSchwann cells capable of generating protective myelin over nerves finds researchLipid-lowering drugs are underutilized for preventing atherosclerotic cardiovascular diseaseThe most common side effects of Vyleesi are nausea and vomiting, flushing, injection site reactions and headache. About 40% of patients in the clinical trials experienced nausea, most commonly with the first Vyleesi injection, and 13% needed medications for the treatment of nausea. About 1% of patients treated with Vyleesi in the clinical trials reported darkening of the gums and parts of the skin, including the face and breasts, which did not go away in about half the patients after stopping treatment. Patients with dark skin were more likely to develop this side effect.In the clinical trials, Vyleesi increased blood pressure after dosing, which usually resolved within 12 hours. Because of this effect, Vyleesi should not be used in patients with high blood pressure that is uncontrolled or in those with known cardiovascular disease. Vyleesi is also not recommended in patients at high risk for cardiovascular disease.When naltrexone is taken by mouth, Vyleesi may significantly decrease the levels of naltrexone in the blood. Patients who take a naltrexone-containing medication by mouth to treat alcohol or opioid dependence should not use Vyleesi because it could lead to naltrexone treatment failure.In 2012, the FDA identified female sexual dysfunction as one of 20 disease areas of high priority and focused attention. The FDA held a two-day meeting in October 2014 to advance the agency’s understanding of female sexual dysfunction. During the first day of the meeting, the FDA solicited perspectives directly from patients about their condition and its impact on daily life. In 2016, the FDA published a draft guidance titled “Low Sexual Interest Desire and/or Arousal in Women: Developing Drugs for Treatment,” to assist companies developing drugs for the treatment of these conditions. The FDA is committed to continuing to work with companies to develop safe and effective treatments for female sexual dysfunction.The FDA granted approval of Vyleesi to AMAG Pharmaceuticals. Source:U.S. Food and Drug Administrationlast_img read more

How quantum computers could steal your bitcoin

first_imgPart of IBM Research’s quantum computer. Credit: IBM Research/Flickr, CC BY-ND This article was originally published on The Conversation. Read the original article. Bitcoin and cryptocurrency for n00bs Citation: How quantum computers could steal your bitcoin (2018, July 16) retrieved 18 July 2019 from https://phys.org/news/2018-07-quantum-bitcoin.html Can you access bitcoin without the private key?In fact, anybody who can solve one of the puzzles on the blockchain without the secret hint can access the funds stored there. Hence the only distinguishing feature of the intended recipients is that they can solve these puzzles more efficiently than others, thanks to the secret hint only they know.Most puzzles used for bitcoin take the form of signatures. Namely, bitcoin transactions are electronically signed using a really complicated algorithms based on what mathematicians call elliptic curves. The idea is that creating such a signature is prohibitively difficult for any computer unless one holds the secret key, and that it can be verified easily using the public key.However, while these signatures indeed appear impossible to fake for today’s computers, quantum computers can potentially solve them very efficiently. This is possible because quantum computers are not restricted to processing digital information, but instead perform calculations directly using the quantum mechanical interactions that dominate physics at a microscopic scale.Researchers are still trying to find out exactly what kind of problems quantum computers are superior at solving. But we do know that two problems underlying much of today’s cryptography happen to be ones that tomorrow’s quantum computers may be able to solve quite efficiently (for the experts at home, in addition to solving elliptic curves, the other problem is finding the prime factors of a number).In particular, elliptic curve cryptography can be broken running a variant of Shor’s algorithm. This algorithm is able to compute the secret key from the public key efficiently, and thus is able to create signatures quickly once the public key is revealed. This can’t be done using today’s computers. In fact, we believe that only quantum computers will ever be able to perform this computation.How would a thief with a quantum computer steal bitcoin?The current mechanics of bitcoin mean the public key is only revealed with the signature when a transaction is proposed to the network. Hence there is a very short window of opportunity for a quantum computer to calculate the private key from the public key and present an alternative signed transaction (for example, making Bob’s money go to the thief instead of to Alice). We can think of this attack as analogous to robbing a customer just before he enters a bank to deposit money.Making things worse, for many bitcoin transactions the public key is actually already known and stored on the blockchain. This removes the timing constraint for the above attack and allows a thief to steal funds even if no transaction is proposed. This affects approximately a third of the bitcoin market capital, or several tens of billions of dollars. This is more like a traditional bank robbery where the thief doesn’t have to wait for a customer to make transactions.It is hard to predict when quantum computers will be strong and fast enough to perform these attacks, but it is fair to assume that we are safe for at least the next ten years.Can we make bitcoin safe?It is important that researchers find alternatives to elliptic curve cryptography that are resistant against attacks by quantum computers.And although no standard has emerged yet, alternative cryptocurrencies that take quantum computers into account are being developed right now. So even if bitcoin might ultimately succumb to quantum computers, blockchain and cryptocurrencies will certainly live on. Provided by The Conversationcenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Bitcoin transactions are essentially a series of puzzles stored in public on the blockchain. The puzzles used to protect bitcoin are so complex that current computer technology isn’t powerful enough to crack them.But quantum computers could crack these puzzles in coming decades. Here’s how it could happen to your bitcoin.How does the encryption behind bitcoin work?Traditional currencies rely on trusted intermediaries like banks to verify and record all monetary transactions. The cryptocurrency economy instead relies on a public ledger – the blockchain – which is maintained by all honest participants of the bitcoin network. Banks are usually required by law to authenticate the sender and recipient of any transaction. But cryptocurrency transactions can, in principle, be performed anonymously.Imagine a hypothetical potential bitcoin recipient called Alice. She must first create a unique and extremely difficult puzzle that can only be easily solved using a secret hint (called a private key) that she keeps to herself. Moreover, it must be easy to verify that the solution is correct. This is done using another hint (called a public key). After this happens, Alice sends the puzzle out to anybody who would like to send bitcoins to her.Now imagine a sender; let’s call him Bob. If Bob wants to send bitcoin to Alice, he will submit a transaction to the network that contains two ingredients: Alice’s puzzle and a solution to a puzzle unlocking funds sent to Bob in a previous transaction. He’ll also reveal the public key used to verify the solution. If the solution is verified by the different participants of the network, they will assume that Bob is indeed authorised to spend his bitcoin and accept the transaction into the blockchain. Alice can now spend the funds by revealing a solution to her puzzle. In this way, the full ledger of bitcoin transactions is entirely public, while the identities of the bitcoin owners are protected. Explore further Cryptocurrencies like bitcoin have recently captured the public’s imagination because they offer an exciting alternative to traditional monetary systems.last_img read more