Tagged in: 上海后花园

NEW YORK NY – Bloomsbury Auctions announced it wi

first_imgNEW YORK, NY – Bloomsbury Auctions announced it will auction 371 salt and albumen photographs contained in the five-volume Baron von Brandis compilation entitled, “The Countries of Amur, Eastern Siberia, Western Siberia and the Urals.”The photographs which date from the 19th century will be offered 17 October 2008 at the house’s New York gallery located at 6 West 48th Street here.For further information, call (212) 719 – 1000 or visit www.bloomsburyauctions.comlast_img

Rep Wendzel to host local coffee hour

first_img25Apr Rep. Wendzel to host local coffee hour Categories: Wendzel News State Representative Pauline Wendzel announced plans to meet with residents of Southwest Michigan during a morning coffee hour.The coffee hour will take place on Monday, April 29th at the Early Bird Eatery, 9735 Red Arrow Hwy in Bridgman from 10 to 11 a.m.“Last months ‘Pints with Pauline’ was a big hit,” Wendzel said.  “I look forward to rotating morning and evening outreach events all over the district to speak with as many constituents as possible.”No appointment is necessary. Those unable to attend are invited to contact her Lansing office by phone at 517-373-1403 or email PaulineWendzel@house.mi.gov.last_img

PanEuropean broadcast group RTL has said that its

first_imgPan-European broadcast group RTL has said that its European online and on-demand platforms collectively were up 25% year-on-year and topped 2.4 billion views of professionally produced content in 2012. Mobile views grew 58% to 118 million in Germany and 119% to 70.5 million in France.RTL said that its FremantleMedia unit is the highest rated TV producer on YouTube and that digital operations helped drive revenue growth of nearly 20% at the producer and distributor.FremantleMedia revenue for 2012 hit €1.71 billion, up 19.7% on 2011’s €1.42 billion, though earnings before interest, tax and amortisation dropped 3.5% to €138 million.RTL said Fremantle had registered 4.5 billion views across 101 channels on video-sharing site YouTube, which made it the “highest rated TV producer” on the platform.RTL Group also pointed to FremantleMedia’s strength in format production and distribution. Fox’s American Idol in the US and Britain’s Got Talent on ITV1 in the UK were key performing formats, along with local versions of The Farmer Wants a Wife in France, the Netherlands and Germany.Overall RTL Group revenue was €5.99bn, up 4% year-on-year. However, mirroring Fremantle, earnings were down. EBITA stood at €1.07 billion, compared with the €1.13 billion posted the previous year.Divisions driving growth besides Fremantle included its German operation, Mediengruppe RTL Deutschland, which saw revenue climb 3.7% to €1.91 billion and EBITA grow 1.6% to €27.7 million.Co-CEOs Anke Schäferkordt and Guillaume de Posch said the results showed the company was well positioned to “develop a leading position in high-growth markets such as online video advertising”.“Our expertise in content and creativity has already proven to be a competitive advantage for the non-linear TV world as audiences are attracted by hit formats and established brands, across all screens and devices,” the added.last_img read more

David ParkhouseDerry City FCDerrys twogoal hero

first_img David ParkhouseDerry City FCDerry’s two-goal hero David Parkhouse picks the winning tickets for monthly drawmonthly drawwaterford DAVID Parkhouse was on the score sheet twice on Monday night in Derry City’s emphatic win over Waterford at the Ryan McBride Brandywell Stadium.On Tuesday night, the hero of the game was helping out with the Derry City FC Monthly Draw for July. David’s midas touch off the pitch helped Peter McDuff win £850 and Ciaran Doherty picked up £300. ShareTweetcenter_img David and the team will be back in action this Friday, August 2, when the Candystripes travel to bottom of the leagues side UCD (kick off 7.45 pm)A win for Derry could help them leapfrog Bohemians into third place on goal difference. Derry will be hoping Finn Harps can do them a favour on the same night if they can beat Bohs at Finn Park in Ballybofey (kick off 8 pm).Derry’s two-goal hero David Parkhouse picks the winning tickets for monthly draw was last modified: July 30th, 2019 by John2John2 Tags:last_img read more

•  Investors like MLPs because of their high yield

first_img •  Investors like MLPs because of their high yields… Regular readers know that the Federal Reserve cut its key interest rate to zero in 2008. It’s left it there ever since. This pushed interest rates to ridiculously low levels, making it difficult for investors to earn a decent yield. Take the 10-year Treasury, for example. In 2007, its yield averaged 4.63%. Today, it yields just 2.05%. From the beginning of 2009 through June 2014 (when energy prices peaked), AMZ returned 294%. Meanwhile, the S&P 500 returned just 110%. One big reason for AMZ’s great performance is that MLPs were one of the only investments where investors could earn a decent yield. Many investors bought MLPs thinking they were safe ways to invest in America’s booming energy sector. After all, MLPs were supposed to earn steady income streams that didn’t depend on the price of oil, natural gas, or coal… Earlier this year, The Wall Street Journal explained why MLPs are supposed to be insulated from volatile energy prices. To manage swings in fuel prices, the partnerships have contracts that guarantee them minimum prices for oil and gas. Such contracts, or hedges, will help them weather lower prices in the near term. In the same article, The Wall Street Journal noted that many of those hedges expired in 2015. That’s been a big problem. The price of oil has fallen 48% over the past year. And the price of natural gas has fallen 39%. Many MLPs are now exposed to these weak prices. And it’s starting to show up on their income statements: Energy Transfer Partners (ETP) is a pipeline MLP worth $22 billion. The company’s quarterly revenues fell by an average of 43% during the first two quarters of 2015. Last year, the company averaged 13% quarterly revenue growth during the first and second quarters. Magellan Midstream Partners (MMP) is a pipeline MLP worth $16 billion. Its quarterly revenues dropped 9% during the first and second quarters of 2015. Last year, the company’s revenues increased 27% on average during the same two quarters. MarkWest Energy Partners (MWE) is another pipeline MLP. It’s worth $9 billion. Its quarterly revenues fell by 10% on average during the first two quarters of 2015. Last year, the company’s revenues increased 31% on average during the first two quarter. •  MLPs have crashed with the rest of the energy market… The chart below shows the performance of AMZ over the past year. As you can see, it’s down 36% in just twelve months. Regards, Justin Spittler Delray Beach, Florida October 06, 2015 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful. – Urgent Announcement: Banking Insider Warns: “If you were born before 1969, you should move 20% of your savings here now.” More than 60,000 Americans are now following “Ronald Reagan’s Secret Retirement Income Plan,” and moving their money out of the traditional financial system into one little-known safe haven where wealth grows tax-free… This 100% legal “tax shelter” has proven—over 232 years—to protect and grow wealth in times of recession, depression, inflation, and even dollar weakness.  Joe Biden, Hillary Clinton, and at least 52 other Washington officials have already moved a portions of their cash here…  The big banks have already moved $143 billion here… and plan to move billions more. Now, you can find out all the details for FREE. Click here to claim your free starter kit. The “toll takers” of the energy industry have crashed… The Alerian MLP Index (AMZ) lost 22% last quarter. It was the index’s worst quarter ever. AMZ lost an incredible 15% in September alone. AMZ tracks 50 of the biggest master-limited partnerships, or MLPs. Most MLPs act as “toll roads” for the energy sector. Natural gas pipeline companies are a common type of MLP. Unlike natural gas producers that look for natural gas and pull it out of the ground, a pipeline MLP helps move natural gas from one place to another. These companies typically charge a set fee for each cubic foot of gas they transport, regardless of the price of natural gas. MLPs trade on public stock exchanges, but they’re a little different from most stocks. They don’t pay corporate taxes. And they have to distribute nearly all of their income to investors. Because of this unique structure, MLPs generally pay high yields. AMZ currently yields 7.99%. Meanwhile, the S&P 500 yields just 2.25%. •  The market for MLPs has exploded in recent years… The number of MLPs jumped from 32 in 2003 to over 100 last year. And between 2008 and 2014, the value of the MLP industry jumped from under $100 billion to over $500 billion. America’s booming energy market helped fuel this explosive growth. Regular readers know that U.S. oil production has more than doubled over the past six years. U.S. natural gas production also jumped 40% between 2004 and 2014. More oil and natural gas production means more oil and natural gas must be processed, transported, and stored…which benefits MLPs. Recommended Links Doug Casey Issues Warning to America From His Secluded 1,235 Acre Farm: “This is a very bad situation. The U.S. is digging itself in deeper and deeper.” Click here to learn more. — A big reason for the selling is that investors are worried MLPs will cut their payouts. So far, that hasn’t happened… Not one midstream MLP cut its distribution from the beginning of 2014 through the second quarter of 2015. In fact, the 25 midstream MLPs tracked by the index actually raised distributions a total of 111 times during that timeframe. • But that doesn’t mean you should buy MLPs… E.B. Tucker, editor of The Casey Report explains why MLPs are dangerous: Many investors blindly buy MLPs for their rich yields without understanding what they’re buying… MLPs are legally required to pay out at least 90% of their profits to investors. After MLPs pay investors, there’s almost no money left to invest back in the business. That means MLPs have only two options when they need money to pay for repairs, maintenance, and upgrades. They can issue new stock, or they can raise money by selling bonds. Neither option is attractive for MLP investors. The bond market doesn’t want to loan MLPs money right now. MLPs that desperately needs cash are going to pay out the nose to get it. The only other choice is to issue more shares…which reduces the value of existing shares. Chart of the Day MLPs pay some of the highest yields in the market… Today’s chart compares AMZ’s yield to other types of investments. As you can see, MLPs pay roughly triple what stocks in the S&P 500 and Dow Jones Industrial Average (DJIA) yield. MLPs also pay twice as much as real estate investment trusts (REITs) and utilities. However, this doesn’t mean MLPs are a good investment. As we explained earlier, MLPs have several problems including falling revenues and a lack of good financing options. We don’t recommend buying MLPs as a group at today’s prices.last_img read more

The next time you swat a fruit fly in your kitchen

first_imgThe next time you swat a fruit fly in your kitchen, take heart from the fact that people have apparently been struggling with these fly infestations for around 10,000 years.A study published Thursday suggests Drosophila melanogaster first shacked up with humans when the insects flew into the elaborately painted caves of ancient people living in southern Africa.That’s according to a report published Thursday in the journal Current Biology.Scientists say the flies would have been following the alluring smell of stored marula fruit, which were collected and stored by cave-dwelling people in Africa. This tasty yellow fruit was a staple in the region in those days — and was also the fruit that wild flies apparently evolved to depend on in nearby forests.The humble fruit fly now lives with humans all over the planet and is one of the world’s most studied creatures. For more than a century, biology and medical laboratories have depended on this fly — one scientist notes that at least nine times, the Nobel Prize in Physiology or Medicine has been awarded for research on Drosophila. One of those prizes was won by Thomas Hunt Morgan of Columbia University, whose fly research in the early 1900s plucked this species from obscurity and transformed it into a mainstay of genetics.”It’s small; it’s cheap to raise; it has interesting genetics,” explains Thomas Kaufman, a biologist at Indiana University in Bloomington. “We think that flies are quite charismatic. They’re wonderful. They’re beautiful little animals, and we love them. Seriously.”But despite all that love and study, the origins of this fly, and how it first moved in with people, have been a mystery.”I’ve been wondering about this for the past 20 years,” says Marcus Stensmyr, a biologist at Lund University in Sweden who uses these flies to study the olfactory system. “It’s really been kind of a life-long ambition, if you wish, to find where they come from.”Scientists have known for decades that, like people, the flies seem to have started out in Africa — somewhere.”You find them in your kitchen. You find them in my kitchen — you find them in everyone’s kitchen,” says Stensmyr. “But if you go out into the forest, you simply don’t find them.”Recently, researchers collected flies from around Africa and looked at their genes. They found that the greatest genetic diversity was found in flies from Zambia and Zimbabwe, suggesting that this species got its start in the southern-central region of the continent.But trips to that region failed to turn up much of anything.”After a number of failed excursions down to Africa,” says Stensmyr, “we thought, ‘OK, so maybe they are associated with some specific fruit in their original home.’ “Stensmyr and his colleagues studied a long list of possible fruits, looking for all the features that D. melanogaster is known to prefer. The flies favor citrus fruits — like oranges, for example.”We came to a candidate fruit — that was marula fruit,” says Stensmyr. The yellow fruit is about the size of a large plum, with a hard stone in the middle. “It has a sweet and nice taste.”The researchers traveled to the woodlands of the Matobo National Park in Zimbabwe. They found fruiting marula trees and put out traps. Bingo — they caught D. melanogaster.”We found tons of flies,” Stensmyr recalls.Further study showed that wild D. melanogaster strongly prefer marula fruit over oranges.What’s more, so does a breed of fly that’s commonly used in labs. This strain was established in 1916 from a fly population in Canton, Ohio.”They actually have retained the preference for marula,” says Stensmyr. “They would go for the marula as well.”The researchers isolated one particular chemical in this fruit — ethyl isovalerate — that seemed particularly important. Flies that were given a choice between marula and oranges spiked with this chemical failed to pick one over the other, suggesting that the two choices seemed the same to the flies.All of this provides an intriguing clue for how these insects may have started to make their home with people. Near where the researchers found the wild flies, there are caves where the San tribes once lived. These people left behind beautiful cave paintings — as well as the pits of marula fruit that they had eaten. From one cave alone, excavators turned up 24 million marula stones.”They really, really loved marula,” says Stensmyr, who points out that the stones found date from about 12,000 years ago to about 8,000 years ago. “During the times when these caves were inhabited, the San people must have brought enormous quantities of marula into the caves.”That means marula was likely stored there, and available there long after the marula in the forest had been eaten up by wildlife. The strong smell of all this marula would have attracted the flies.To test whether or not wild flies would actually enter a cave, the research team put traps baited with fermenting marula along the far wall of the Nswatugi cave. Sure enough, over a period of a few days, these traps caught a number of D. melanogaster flies.The study, and the story it tells, has completely delighted other scientists who study fruit flies.”I particularly liked going and catching the flies in the painted caves,” says Kaufman. “That was inspired. It’s really a neat paper.””I thought it was fantastic,” agrees Celeste Berg, a developmental geneticist at the University of Washington, Seattle who has used flies in her research for 30 years. “I thought their data was really quite striking.”Berg says she wonders exactly how the flies would have spread from these caves to the rest of the world.”I think it’s exciting to learn the origins of fruit flies and, even if you’re not an ecologist or a population geneticist, I think it’s just natural to be interested in the history of the organism you study,” says Berg. “I had assumed that fruit flies liked all kinds of fruit — especially bananas. I didn’t even realize that they preferred citrus. And it’s not even really citrus that they prefer; they prefer this particular marula plant, which I also had never heard of.”Debbie Andrew, a developmental biologist at the Johns Hopkins School of Medicine who has worked with fruit flies for four decades, also says she loved the paper.”They built a good story,” says Andrew. “It’s very hard to prove something that happened 10,000 years ago or more. I like the story.”As to whether all the details are right, she says, “I don’t know; it does seem plausible, based on the amount of marula fruit stones they found in the cave.”Based on this paper, says Andrew, the old saying, “time flies like an arrow, and fruit flies like a banana,” should really be changed.”Time flies like an arrow,” she says, “and fruit flies like an orange, or a marula fruit, or perhaps an orange spiked with ethyl isovalerate.” Copyright 2018 NPR. To see more, visit https://www.npr.org.last_img read more

The government wants to increase the number of peo

first_imgThe government wants to increase the number of people who use personal health budgets (PHBs) to choose their own health and social care support from 40,000 to as many as 200,000 over the next five years.It hasapproved extending legal rights to PHBs to disabled people eligible for fundingfrom NHS wheelchair services, and those eligible for aftercare services undersection 117 of the Mental Health Act.But it alsosignalled that these rights would eventually be extended to other groups,including people with ongoing social care needs who also make regular andcontinuing use of particular NHS services; people leaving the armed services whoare eligible for ongoing NHS services; and autistic people and those withlearning difficulties who are eligible for ongoing NHS care.PHBs giveindividuals a pot of money to spend on their health and wellbeing needs, inagreement with a healthcare professional.Manydisabled campaigners have supported the expansion of PHBs, arguing that theycould help deliver independent living for disabled people, whileothers have raised concerns that they could be part of a creepingprivatisation of the NHS, and that they are based on the same “failing” modelused with social care personal budgets.Currently,only adults receiving NHS Continuing Healthcare, and children and young peoplewho receive continuing care, have the right to a PHB.But the Department of Health and Social Care (DHSC, pictured) and NHS England have now published their response to a consultation, which ended last June, on extending that right to other groups and the possibility of extending that to include a right to have the PHB managed through direct payments.The governmentresponse says people “value being involved in the planning of their care, beingable to make choices and personalise their support so it best meets their needs”.And it saysthe evidence suggests that those who can do that “are more satisfied with theircare, have better outcomes, and are able to explore more innovative approachesto meet their needs”.Theconsultation also asked for views on whether the government should bringtogether PHBs and social care personal budgets – and educational needs in thecase of disabled children and young people – into an integrated personalbudget.Theconsultation results suggested widespread support for a further expansion of PHBs,with 87 per cent (330 of 379 people) of those who answered the question sayingthey believed that autistic people and those with learning difficulties who areeligible for ongoing NHS care should have a legal right to a PHB or anintegrated personal budget.And morethan 90 per cent supported extending the right to a PHB or integrated personalbudget to those using NHS wheelchair services, with 87 per cent saying thisgroup should also have a right to receive that budget via direct payments, ifappropriate.DHSC and NHSEngland said their ambition was “to move towards joined up and integratedprovision across health and social care” through a “comprehensive model ofintegrated, personalised care” and with PHBs and integrated personal budgets “akey component” of this plan.These plansare set out in the new NHS LongTerm Plan.Thegovernment and NHS England said they believed that more than 200,000 people wouldhave a PHB by 2023-24, including many from the five groups they consulted onlast year.Although thegovernment is only taking forward legislation on those using wheelchairservices and mental health aftercare, it says it will “continue to furtherexplore both the other groups we consulted on, and additional groups who webelieve could also benefit from having a right to have a personal health budget”.Someadditional groups that could benefit and were mentioned by those taking part inthe consultation included people with dementia, people receiving end-of-lifecare, and those receiving community equipment.NHS Englandsaid it would continue to work with clinical commissioning groups to “designand test” the use of PHBs for other groups of people and service areas.Careminister Caroline Dinenage said: “I’ve seen first-hand how personal health budgets can givepeople a new lease of life, granting them the ability to enjoy their lives tothe full. “Thesebudgets help to join up health and social care services, improving people’sexperiences and outcomes whilst ensuring value for money for taxpayers.“We are therefore extending access so many more people can benefit, a key part of our NHS Long Term Plan which will see personalised care become the norm for millions more.”A note from the editor:Please consider making a voluntary financial contribution to support the work of DNS and allow it to continue producing independent, carefully-researched news stories that focus on the lives and rights of disabled people and their user-led organisations. Please do not contribute if you cannot afford to do so, and please note that DNS is not a charity. It is run and owned by disabled journalist John Pring and has been from its launch in April 2009. Thank you for anything you can do to support the work of DNS…last_img read more

Fish slime could be a potential source of antibiotics finds study

first_imgBy Dr. Ananya Mandal, MDMar 31 2019With the advent of multi-drug resistant bacteria and lack of new antibiotics, researchers have been on the lookout for new molecules that can fight these pathogens. A team of researchers have now identified a slimy mucous coating of young fish as a potential source for antibiotics that could fight resistant infections such as MRSA (Methicillin Resistant Staphylococcus aureus). The results of the study were presented at the American Chemical Society (ACS) Spring 2019 National Meeting & Exposition.Lead researcher Sandra Loesgen from the Oregon State University, in a statement said, “We believe the microbes in the mucus add chemistry to the antiseptic power of the mucus and that new bioactive compounds might be discovered from the fish microbiome…For us, any microbe in the marine environment that could provide a new compound is worth exploring.”She added that there are several chemical reagents in the human microbiota (present in the gut and mucosal surfaces of humans) as well as on marine life. These have not yet been explored she said. She said that there us a mucus coating on the surface of fish. It is rich in microbes that protect the fish. This is a thick viscous slimy substance that can protect the fish from bacteria, fungi and viral attacks from its environment. The slime is capable of trapping these pathogens before they can penetrate the skin. This slime is also found to be rich in complex sugars called polysaccharides and complex proteins called peptides. These compounds have shown antibacterial activity say the researchers.Related StoriesBioactive hydrogel promises faster wound healingMediterranean diet may improve memory in type 2 diabeticsAncient epigenetic change deactivates some genes linked to cancerMolly Austin, an undergraduate chemistry student, who was part of some of the experiments said, “Fish mucus is really interesting because the environment the fish live in is complex. They are in contact with their environment all the time with many pathogenic viruses.”A co-author on the study, Erin (Misty) Paig-Tran, from California State University, Fullerton, provided this team with the mucus that was obtained from the young ones of deep-sea and surface-dwelling fish from the Southern California coast. They noticed that the mucus was more abundant among young fish as they needed to fight off infections more because of their immature immune systems. Loesgen, along with Austin and another graduate student Paige Mandelare, looked at the mucus and its capacity to fight off 47 different strains of bacteria.The team was surprised to see that five extracts of the slime could fight off MRSA while three of the extracts were capable of fighting off fungus Candida albicans. One particular strain of bacteria from the surface of Pacific pink perch was found to fight both MRSA as well as a cell line from colon cancer. The team is also on the lookout for extracts that could fight Gram-negative bacteria – Pseudomonas aeruginosa, which is difficult to treat.The researchers add that their experiments might help reduce antibiotic use in fish farming as well. The reduced use of antibiotics on fish would enhance the production of this slime with antibacterial properties they explain.Loesgen said that as of now they are not clear on the natural antimicrobial picture on fish. They add that they do not know if the extracts they studied from the fish were normally found. Their next step in the research would be to understand that normal microbiome over fish surface, explains Loesgen. Source:https://www.eurekalert.org/pub_releases/2019-03/acs-fsa022119.phpcenter_img Staphylococcus aureus (MRSA) bacteria 3d illustration: Credit: Shutterstocklast_img read more

CPaths PRO Consortium announces FDA qualification of new asthma clinical outcome assessment

first_img Source:https://c-path.org/c-path-receives-qualification-from-fda-for-the-asthma-daytime-symptom-diary-adsd-and-the-asthma-nighttime-symptom-diary-ansd/ Reviewed by James Ives, M.Psych. (Editor)Apr 10 2019Critical Path Institute’s (C-Path) Patient-Reported Outcome (PRO) Consortium announces U.S. Food and Drug Administration (FDA) qualification of two new clinical outcome assessment tools: the Asthma Daytime Symptom Diary (ADSD) and the Asthma Nighttime Symptom Diary (ANSD). The qualification of the ADSD and the ANSD represents a major milestone for the PRO Consortium and specifically for the Asthma Working Group. It is the culmination of a multi-year collaboration between FDA’s Center for Drug Evaluation and Research (CDER) and the PRO Consortium.The ADSD and the ANSD are each 6-item, PRO measures developed to document the core symptoms of asthma in adults and adolescents with a clinical diagnosis of mild to severe persistent asthma.”Asthma symptoms have a substantial impact on patients, including limiting the ability to participate in daily activities and disrupting sleep. The qualification of the ADSD and the ANSD is a significant advance in our ability to document the patient’s experience of asthma symptoms in clinical trials,” stated Linda Nelsen, MHS, Senior Director and Head, Patient Centered Outcomes, Value Evidence and Outcomes, at GlaxoSmithKline and co-chair of the PRO Consortium’s Asthma Working Group.”The development of the ADSD and ANSD represents a close collaboration of clinicians, measurement experts, and regulators focused on developing a robust measure of asthma symptoms,” Nelsen added. “Most importantly, the ADSD and ANSD were developed with extensive involvement of people living with asthma to clearly define the experience of asthma symptoms and the relative importance of those symptoms from their perspective. Thus, the ADSD and ANSD bring the patient’s voice into clinical trials in a way that allows the quantification of important concepts of patient experience in treatment.”Related StoriesWorld Asthma Day: How climate change is increasing cases of asthmaGrowing up on farm with animals may half risk of asthma and allergies, suggests studyChaos in the house and asthma in children – the connectionSonya Eremenco, MA, Associate Director of the PRO Consortium, said, “Sponsors of asthma treatment trials have been using a variety of asthma symptom measures over the years, but we now have a standard set of symptom measures created via a multi-stakeholder, precompetitive collaboration that can be used in asthma drug development programs. This is a significant step toward providing enhanced consistency and comparability in the evaluation of the patient-focused clinical benefit from new asthma drugs.”CDER has determined that the ADSD and ANSD have demonstrated adequate evidence of content validity and cross-sectional measurement properties (i.e., internal consistency reliability, test-retest reliability, convergent validity and known-groups validity) to measure symptoms of asthma in adolescents and adults.Drug developers seeking to use the ADSD or ANSD as a primary or secondary endpoint measure in confirmatory studies should discuss plans with the appropriate CDER review division. It is recommended to use the ANSD with the ADSD to better characterize the drug effect and understand the measurement properties of each instrument. Further evaluation is needed on the instruments’ longitudinal properties and the interpretation of clinically meaningful within-patient change in score.last_img read more

CGM evaluations in longterm islet transplant recipients show nearnormal glycemic profiles

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 10 2019Continuous glucose monitoring (CGM) evaluations in islet transplant recipients who have been insulin independent for an average of 10 years show near-normal glycemic profiles and time-in-range metrics, according to data presented by the Diabetes Research Institute at the University of Miami Miller School of Medicine.The findings, which were accepted as a late-breaking poster at the American Diabetes Association (ADA) 79th Scientific Sessions, June 7 – 11, 2019 in San Francisco, CA, demonstrate that islet transplantation can be a successful long-term cell therapy for select patients with type 1 diabetes.The DRI team evaluated five of its adult subjects who received intrahepatic (in the liver) islet transplants between 2002 – 2010 and have since remained insulin independent for seven to 16+ years. During their last study follow-up, the subjects completed a 7-day, non-blinded CGM to assess their glycemic profiles.Compared to current recommended CGM goals for adults with type 1 diabetes on a hybrid closed-loop system, all patients demonstrated improved CGM time-in-range, reduction in glucose variability, and prevention of hypoglycemia. A sampling of the results is as follows:In addition, time in the more stringent glucose range of 70-140 mg/dL was 83.1%, with a mean sensor glucose (SG) value of 116 mg/dL and an average HbA1c of 5.7%. The ADA’s recommended HbA1c goal is <7% for adults with diabetes. Using continuous glucose monitoring, we now have the ability to accurately evaluate patients' glucose profiles and their variability. The CGM data we have obtained from our islet transplant patients clearly demonstrates that islet transplantation can result in glucose levels that are close to those in people who do not have type 1 diabetes, even 10 years or more after undergoing the cell-replacement procedure."David Baidal, M.D., assistant professor of medicine and member of the DRI's Clinical Islet Transplant Program One of the principal investigators of the study, Dr. Baidal is presenting the results at the ADA conference."Although not all subjects remain insulin independent, like the subjects described in this presentation, after an islet transplant a significant number of them continue with excellent graft function for over 10 years that allows them to have near-normal glucose metabolism in the absence of severe hypoglycemia on small doses of insulin," said Rodolfo Alejandro, M.D., director of the Clinical Cell Transplant Program and also a principal investigator of the study. Dr. Alejandro will be presenting these results at the upcoming 17th World Congress of the International Pancreas & Islet Transplant Association, July 2-5, 2019 in Lyon, France.Related StoriesImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsALS mobility and survival could be improved by increasing glucoseHigh-fat, low-carbohydrate diet may improve brain function and memory in older adults"This report confirms the superiority of transplantation of insulin-producing cells compared to insulin therapy, with glucose control results that were even better than the goals of CGM in hybrid closed-loop systems. Hopefully, this will be of assistance in bringing islet transplantation closer to FDA approval, allowing the treatment to be made available to U.S. patients, as has already been the case in several other countries, for many years," said Camillo Ricordi, M.D., Stacy Joy Goodman Professor of Surgery and director of the Diabetes Research Institute, who was recently named the world's leading expert in islet transplantation by Expertscape. Dr. Ricordi is well-known for inventing the machine (Ricordi Chamber) that made it possible to isolate large numbers of islet cells from the human pancreas and for performing the first series of successful clinical islet transplants that reversed diabetes after implantation of donor purified islets into the liver of recipients with diabetes.In type 1 diabetes, the insulin-producing islets cells of the pancreas have been mistakenly destroyed by the immune system, requiring patients to manage their blood sugar levels through a daily regimen of insulin therapy.Islet transplantation has allowed some patients to live without the need for insulin injections after receiving a transplant of donor cells. Some patients who have received islet transplants have been insulin independent for more than a decade, as DRI researchers have published. Currently, islet transplantation remains an experimental procedure limited to a select group of adult patients with type 1 diabetes.In 2016, the National Institutes of Health-sponsored Clinical Islet Transplantation Consortium reported results from its Food and Drug Administration (FDA)-authorized Phase 3 multi-center trial, of which the DRI was a part, indicating that islet transplantation was effective in preventing severe hypoglycemia (low blood sugar levels), a particularly feared complication in type 1 diabetes that can lead to seizures, loss of consciousness and even death.The study was a significant step toward making islet transplantation an approved treatment for people with type 1 diabetes and reimbursable through health insurance, as it is in several other countries around the world.center_img Source:Diabetes Research Institute Foundationlast_img read more

FDA approves new drug to treat hypoactive sexual desire disorder in premenopausal

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 23 2019The U.S. Food and Drug Administration today approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. There are women who, for no known reason, have reduced sexual desire that causes marked distress, and who can benefit from safe and effective pharmacologic treatment. Today’s approval provides women with another treatment option for this condition. As part of the FDA’s commitment to protect and advance the health of women, we’ll continue to support the development of safe and effective treatments for female sexual dysfunction.”Hylton V. Joffe, M.D., M.M.Sc., director of the Center for Drug Evaluation and Research’s Division of Bone, Reproductive and Urologic Products HSDD is characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to a co-existing medical or psychiatric condition, problems within the relationship or the effects of a medication or other drug substance. Acquired HSDD develops in a patient who previously experienced no problems with sexual desire. Generalized HSDD refers to HSDD that occurs regardless of the type of sexual activity, situation or partner.Vyleesi activates melanocortin receptors, but the mechanism by which it improves sexual desire and related distress is unknown. Patients inject Vyleesi under the skin of the abdomen or thigh at least 45 minutes before anticipated sexual activity and may decide the optimal time to use Vyleesi based on how they experience the duration of benefit and any side effects, such as nausea. Patients should not use more than one dose within 24 hours or more than eight doses per month. Patients should discontinue treatment after eight weeks if they do not report an improvement in sexual desire and associated distress.The effectiveness and safety of Vyleesi were studied in two 24-week, randomized, double-blind, placebo-controlled trials in 1,247 premenopausal women with acquired, generalized HSDD. Most patients used Vyleesi two or three times per month and no more than once a week. In these trials, about 25% of patients treated with Vyleesi had an increase of 1.2 or more in their sexual desire score (scored on a range of 1.2 to 6.0, with higher scores indicating greater sexual desire) compared to about 17% of those who took placebo. Additionally, about 35% of the patients treated with Vyleesi had a decrease of one or more in their distress score (scored on a range of zero to four, with higher scores indicating greater distress from low sexual desire) compared to about 31% of those who took placebo. There was no difference between treatment groups in the change from the start of the study to end of the study in the number of satisfying sexual events. Vyleesi does not enhance sexual performance.Related StoriesTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTSchwann cells capable of generating protective myelin over nerves finds researchLipid-lowering drugs are underutilized for preventing atherosclerotic cardiovascular diseaseThe most common side effects of Vyleesi are nausea and vomiting, flushing, injection site reactions and headache. About 40% of patients in the clinical trials experienced nausea, most commonly with the first Vyleesi injection, and 13% needed medications for the treatment of nausea. About 1% of patients treated with Vyleesi in the clinical trials reported darkening of the gums and parts of the skin, including the face and breasts, which did not go away in about half the patients after stopping treatment. Patients with dark skin were more likely to develop this side effect.In the clinical trials, Vyleesi increased blood pressure after dosing, which usually resolved within 12 hours. Because of this effect, Vyleesi should not be used in patients with high blood pressure that is uncontrolled or in those with known cardiovascular disease. Vyleesi is also not recommended in patients at high risk for cardiovascular disease.When naltrexone is taken by mouth, Vyleesi may significantly decrease the levels of naltrexone in the blood. Patients who take a naltrexone-containing medication by mouth to treat alcohol or opioid dependence should not use Vyleesi because it could lead to naltrexone treatment failure.In 2012, the FDA identified female sexual dysfunction as one of 20 disease areas of high priority and focused attention. The FDA held a two-day meeting in October 2014 to advance the agency’s understanding of female sexual dysfunction. During the first day of the meeting, the FDA solicited perspectives directly from patients about their condition and its impact on daily life. In 2016, the FDA published a draft guidance titled “Low Sexual Interest Desire and/or Arousal in Women: Developing Drugs for Treatment,” to assist companies developing drugs for the treatment of these conditions. The FDA is committed to continuing to work with companies to develop safe and effective treatments for female sexual dysfunction.The FDA granted approval of Vyleesi to AMAG Pharmaceuticals. Source:U.S. Food and Drug Administrationlast_img read more

Floods affect 8 lakh in Assam 10 dead across Northeast as rains

first_imgFloods affect 8 lakh in Assam, 10 dead across Northeast as rains lash region | 10 pointsHeavy rainfall and floods have affected the entire Eastern and Northeastern India. Over eight lakh people have been affected in Assam while the rain has disrupted life in north Bengal, Sikkim and other states.advertisement India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 23:28 IST An village in Kamrup district of Assam on July 12. (Photo: IANS)Heavy rain and floods have thrown life out of gear in the entire eastern region with over eight lakh people being affected by the overflowing Brahmaputra in Assam. Non-stop rain in north Bengal and Sikkim has triggered several landslides, throwing normal life out of gear.Low-lying areas in north Bengal and Sikkim are also staring at a flood-like situation with the incessant rainfall while in Assam at least 6 people have been killed so far. A total of 10 people have died across three states of Assam, Arunachal Pradesh and Mizoram. Some are feared dead in Bengal.Here are the top 10 developments:1. Road connectivity between north Bengal and Sikkim has been completely disrupted by the continuous rainfall. Rail connectivity has also been disrupted in the Dooars region. Several tourists are struck on the road while two tourist vehicle were drawn into the Teesta River and bodies are yet to recovered due to the rising water levels in Teesta.2. Road connectivity between Siliguri and Sikkim has been shut. Heavy rain is expected till July 14.3. Over eight lakh people have been affected by the flood situation in Assam with more than half of the districts in the Northeastern state submerged under water.4. Barpeta in Assam is the worst hit district with over 85,000 people reeling under the impact of the floods. Six people have lost their lives in Assam so far.5. Animals are fleeing the Kaziranga National Park, the famed habitat of the Great Indian Rhino and a World Heritage site. Authorities have set up road barricades on the national highway passing through the park to limit speeding vehicles.6. The Assam disaster relief force has said nearly 800 villages in 41 revenue circles are under water and about2,000 marooned people have been put up in 53 relief camps and relief distribution centres set up by the district administrations.7. In Arunachal Pradesh, 2 girls were buried in their sleep and three others were injured after a landslide caused a boundary wall to collapse on the hostel building of a school in Tawang district.8. Arunachal capital Itanagar has been witnessing landslips, mudslides and road blockades due to heavy rainfall for several days and the district administration has ordered closure of all schools in Itanagar till Sunday.9. In Mizoram, 2 men have drowned and 390 houses submerged in floods triggered by incessant rain across the state. Disaster management and rehabilitation officials said landslides made many places inaccessible.10. The Itanagar-Naharlagun stretch of NH-415, which is being upgraded to a four-lane highway, is the worst hit by the monsoon fury.(With PTI inputs)Also Read | Incessant rains trigger landslides, bring life to a standstill in Arunachal PradeshAlso Watch | In Depth: Decoding the link between floods and droughtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjee Nextlast_img read more

Complaint against Sisodia Lokayukta seeks clarifications from Delhi BJP chief Manoj Tiwari

first_imgComplaint against Sisodia: Lokayukta seeks clarifications from Delhi BJP chief Manoj TiwariThe Lokayukta has registered Manoj Tiwari’s complaint filed on his behalf by leaders and legal team of the Delhi BJP on July 4.advertisement Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 23:20 IST Delhi BJP chief Manoj Tiwari have been attacking Arvind Kejriwal government alleging “abuse of position” | File photo from PTIHIGHLIGHTSManoj Tiwari has been asked through a notice to present himself at the Lokayukta officeLokayukta registered Manoj Tiwari’s complaint filed on his behalf by leaders and legal team of Delhi BJPAAP has accused Manoj Tiwari of levelling totally “baseless and fabricated” allegationsThe Delhi Lokayukta’s office has sought some clarifications from Bharatiya Janata Party (BJP) MP Manoj Tiwari regarding his complaint against Deputy Chief Minister Manish Sisodia and Public Works Department (PWD) Minister Satyendar Jain over an alleged “scam” in the construction of classrooms in government schools.Manoj Tiwari has been asked through a notice to present himself at the Lokayukta office for his submission on July 30.The Lokayukta has registered Manoj Tiwari’s complaint filed on his behalf by leaders and legal team of the Delhi BJP on July 4.”…Lokayukta has ordered that a notice be sent to the complainant (Tiwari) and his counsel to appear before this forum to make submissions on certain aspects of your complaint which need to be clarified,” the notice issued on July 9 read.Delhi BJP chief Manoj Tiwari and other leaders have been attacking the Arvind Kejriwal government alleging “abuse of position” and “corruption” in the construction of over 12,000 classrooms in government schools.The Aam Aadmi Party (AAP) has hit back, with Deputy Chief Minister sending a notice of criminal defamation against Manoj Tiwari and other BJP leaders.Reacting to the charge, Chief Minister Arvind Kejriwal and Sisodia had dared Manoj Tiwari to get them arrested and challenged him to come out with a list of 10 schools in BJP-ruled states which could be compared with those run by the Delhi government in terms of quality.The AAP has accused Manoj Tiwari and other leaders of his party of levelling totally “baseless and fabricated” allegations.Also Read | AAP govt allocated low budget for MCD-run schools: Delhi BJP chief Manoj TiwariAlso Read | Anti-Romeo squads are good, should be started in Delhi: BJP MP Manoj TiwariAlso Watch | So Shayari: Manoj Tiwari takes on Arvind Kejriwal over Signature Bridge snubFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byMohak Gupta Tags :Follow AAPFollow BJPFollow SisodiaFollow Manoj TiwariFollow Lokyukta Nextlast_img read more